TY -的T1 -十二指肠注入左旋多巴撤军的原因在神经学先进的帕金森病JF -神经学乔- SP - 1669 LP - 1672 - 10.1212 / WNL。首页0000000000001500六世- 84 - 16盟Daniela Calandrella AU -路易吉·m·Romito盟——安东尼奥·e·伊利亚盟——弗兰西斯卡德尔·索伯盟Caterina f . Bagella AU -马西莫·Falsitta盟阿尔贝托·艾博年Y1 - 2015/04/21 UR - //www.ez-admanager.com/content/84/16/1669.abstract N2 -目的:我们进行实际观察首页帕金森病(PD)患者接受十二指肠注入左旋多巴(DLI)来确定哪些不良事件造成治疗停药,当这样的事件发生。方法:所有连续PD患者治疗卡洛Besta神经研究所被包括在内。患者在基线和定期DLI后评估。它们的运动状态评估和不良事件被记录了下来。结果:35 PD患者(15个男性和20名女性)是包括在内。他们收到DLI植入2007年10月至2013年9月。四个患者死亡的原因与过程无关。在研究结束时,21例(60%)仍在接受治疗。DLI在所有患者提供有效的运动控制。停药是最常见的引起的设备——或输注相关的不良事件。 Ten patients of the remaining 31 discontinued DLI. There were 2 main causes of withdrawal: stoma infection (4 patients), and worsening of dyskinesias not manageable with infusion reduction (3 patients). In most patients, discontinuations occurred during the first year after implant. Risk of discontinuation was related to age at implant, but no other demographic or clinical variables.Conclusions: We identified 2 main causes leading to DLI withdrawal during the first year postimplant and suggest adopting measures to prevent such occurrences. Elderly patients are at higher risk of treatment discontinuation.DLI=duodenal levodopa infusion; LEDD=levodopa equivalent daily dose; PD=Parkinson disease; PEG=percutaneous endoscopic gastrostomy ER -