TY -的T1 -高血压,脑血管反应性,和大脑静息状态网络:发现冠状动脉风险发展的年轻人(贲门)大脑MRI∶(P1.088) JF -神经学乔-神经学六世- 84 - 14补充SP - P1.088盟撒迪厄斯海特盟-尼克·布莱恩盟Guray Erus AU - Christos Davatzikos AU -大卫·雅各布斯AU - Mark D 'Esposito AU -刘易斯科拉盟Lenore Launer Y1 - 2首页015/04/06 UR - //www.ez-admanager.com/content/84/14_Supplement/P1.088.abstract N2 -目的:检查脑血管反应性(表格)的大脑区域的静息状态网络(静)有无高血压。背景:脑功能降低,形态学改变之前被检测到,可能代表一个标记在后期生活对大脑功能障碍。减少表格在一个或多个静地区可能是中断的网络个人在中年高血压。设计/方法:受试者541名男性和女性(平均年龄50.4岁,标准差3.5)接受了屏息功能磁共振成像。表格被量化为百分比变化在血氧水平依赖(BOLD)信号激活体素,这是映射到一个共同的大脑模板和对数转换。表格是计算出解剖区域的静,除了枕叶,用作参考。美国心脏协会的指导方针被用来分类科目为高血压前期/高血压和血压正常的人。模型评估意味着表格在大脑区域包括静,枕叶相比,血压状态。结果:表格是静地区相对较低意味着表格在枕叶科目吗/高血压和血压正常的受试者相比,尤其是后扣带/楔前叶(β= -0.072,95 [percnt] CI: -0.115, -0.029)和前扣带(β= -0.059,95 [percnt] CI: -0.104, -0.014)。相比之下,表格是低,但不显著,在内侧额叶(β= -0.039,95 [percnt] CI: -0.080, 0.003),下顶叶(β= -0.029,95 [percnt] CI: -0.067, 0.009)和海马体(β= -0.022,95 [percnt] CI: -0.077, 0.034)。 Findings for the posterior cingulate/precuneus and anterior cingulate were attenuated but remained significant after adjustment for age, race, sex, smoking status, and ApoE4 genotype status. CONCLUSIONS:Reduced CVR may represent diminished vascular functionality for the DMN for individuals with prehypertension/hypertension in mid-life, and may serve as a preclinical marker for future brain changes.Disclosure: Dr. Haight has nothing to disclose. Dr. Bryan has nothing to disclose. Dr. Erus has nothing to disclose. Dr. Davatzikos has nothing to disclose. Dr. Jacobs has nothing to disclose. Dr. D'Esposito has nothing to disclose. Dr. Lewis has received research support from Novo Nordisk. Dr. Launer has nothing to disclose.Monday, April 20 2015, 2:00 pm-6:30 pm ER -