TY - T1的临床评估的自动化通过机器学习和成对比较(P4.205) JF -神经学乔-神经学六世- 84 - 14补充SP - P4.205盟乔纳斯·多恩AU -马库斯D’索萨AU -彼得Kontschieder首页 AU -塞西莉莫里森AU -杰西卡Burggraaff AU -基督教卡姆盟Prejaas Tewarie AU -托马斯·沃格尔盟阿比盖尔Sellen AU -安东尼奥Criminisi AU -弗兰克Dahlke AU -伯纳德Uitdehaag AU -路德维希卡波斯盟彼得下巴Y1 - 2015/04/06 UR - //www.ez-admanager.com/content/84/14_Supplement/P4.205.abstract N2 -目标:开发一个自动化的运动功能障碍的临床评估方法培训机器学习算法与细粒度的临床判断来自两两比较患者的影像记录。背景:许多临床神经学评估尺度遭受可靠性和灵敏度问题,因为它们需要绝对,从临床医生定性判断。首页相反,量化替代措施可能不会传达相同的临床相关的信息。监督机器学习算法允许地图自动代理到临床评估量表测量,从而自动创建一个临床评级。然而,病人数量太有限了标准的机器学习方法,它不可能验证细粒度算法的输出和一个粗粒度的临床评估。在这里,我们专注于扩大残疾量表(eds)对多发性硬化(MS)运动功能障碍的评估。方法:eds小分预计将定制监督机器学习算法应用于运动模式从录像中提取的病人执行预定义的动作。细粒度的捕获的临床判断,我们使用成对比较耐心的视频由神经学家。避免比较所有可能的对视频,我们使用的一种变体TrueSkill™算法目前只有最信息对视频比较的神经学家。结果:我们的小说ensemble-based机器学习算法提供可靠的预测性能的eds小分Finger-to-Nose测试。 The paired comparisons of recorded movement videos by expert neurologists show a finer-grained clinical judgment than provided by the EDSS sub-scores, providing a new potential validation standard. Conclusions: Our generic approach to automate clinical assessment by combining depth sensor recordings with video analysis and supervised machine learning to produce clinically relevant information validated against fine-grained capture of neurological judgment from pairwise comparisons can overcome the limitations of current clinical ratings in reliably capturing subtle changes in disability.Disclosure: Dr. Dorn has received personal compensation for activities with Novartis Pharma AG as an employee. Dr. D'Souza has received personal compensation for activities with Bayer AG, Teva, and Genzyme. Dr. D'Souza has received research support from the University of Basel. Dr. Morrison has received personal compensation for activities with Microsoft Research as an employee. Dr. Morrison has received personal compensation for activities with Microsoft Research as an employee. Dr. Burggraaff has received personal compensation for activities with Novartis. Dr. Kamm has received personal compensation for activities with Biogen Idec, Novartis, Bayer Pharmaceuticals, Merck Serono, Genzyme, and Pfizer Inc. Dr. Tewarie has received personal compensation for activities with Novartis. Dr. Vogel has received personal compensation for activities with Novartis as an employee. Dr. Sellen has received personal compensation for activities with Microsoft Research as an employee. Dr. Criminisi has received personal compensation for activities with Microsoft as an employee. Dr. Dahlke has received personal compensation for activities with Novartis as an employee. Dr. Uitdehaag has received personal compensation for activities with Biogen Idec, Novartis, EMD Serono, Teva Neuroscience, Genzyme Corporation, and Roche Diagnostics Corporation. Dr. Kappos has received personal compensation for activities with Actelion Pharmaceuticals. Dr. Chin has received personal compensation for activities with Genentech, Inc. as an employee.Wednesday, April 22 2015, 7:30 am-12:00 pm ER -