TY -的T1 -急性多发性硬化病变的不同阶段展示了R2 *敏感性和定量映射来自梯度回波(GRE) MRI (P6.110) JF -神经学乔-神经学六世- 84 - 14补充SP - P6.110盟李洁你非盟- Yan张盟Ajay Gupta盟Thanh阮王盟-苏珊Gauthier盟易Y1 - 2015/04/06 UR - http://n.neuro首页logy.org/content/84/14_Supplement/P6.110.abstract N2 -目的:探讨GRE MRI变化在多发性硬化症(MS)病变展示Gadolinium-enhancement T1影像(T1w)。背景:早期病变的钆增强只反映血脑屏障的破坏。GRE数据提供了R2 * (= 1 / T2 *)和定量易感性映射(QSM),它描述体素的下属微观结构完整性和总敏感性,分别。女士在病变的形成,首先是髓鞘脱失,从而降低R2 *。那支离破碎的髓磷脂是由小胶质细胞/巨噬细胞清除,这是一个重要的一步刺激remyelination,和铁沉积也可能发生进一步促进炎症;都有助于易感性增加。我们的研究的目的是捕获的微分阶段早期病变女士利用GRE。设计/方法:本研究分析了MS患者在过去3年在我们的中心,女士的MRI包括多个回波GRE和T1w。Gd-enhancement模式在T1w分为结节性或shell (2 d环)。GRE数据处理来生成R2 *和QSM病变对比测量。 RESULTS:152 gadolinium-enhancing lesions were identified in 34 RRMS patients. On Gd-enhancement patterns, 136(89.5[percnt]) lesions were nodular, 16(10.5[percnt]) were shell. On R2*, All lesions appeared hypointense relative to adjacent NAWM; On QSM, 129(94.9[percnt]) nodular lesions and 3(18.8[percnt]) of shell lesions appeared isointense, and 7(5.1[percnt]) nodular and 13(81.2[percnt]) shell lesions appeared hyperintense. CONCLUSIONS:According to MS lesion literature, nodular Gd-enhancement may represent an earlier stage than shell Gd-enhancement, which is consistent with the observed R2* reduction and QSM unchanging in nodular lesion. In the later stage of shell Gd-enhancement, microglia/macrophages clear myelin debris and some may also carry iron promoting continued inflammation, which is consistent with the observed susceptibility increase in shell lesions. These results suggest that GRE MRI can capture early stages of lesion activity and provides more tissue specific information than gadolinium enhancement. Study Supported by: NIHDisclosure: Dr. Tu has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Gupta has nothing to disclose. Dr. Nguyen has nothing to disclose. Dr. Gauthier has received research support from Biogen Idec, Genzyme Corporation, EMD Serono, and Novartis. Dr. Wang has nothing to disclose.Thursday, April 23 2015, 7:30 am-12:00 pm ER -