% 0期刊文章%一个斯文Schippling % Ilya Ayzenberg %马吕斯Ringelstein %一个塞巴斯蒂安·卢卡斯Orhan Aktas % % Kerstin Hellwig拉尔夫黄金% % T怀孕不防止视网膜变性轴突在多发性硬化(P5.206) % D J神经病学2015% % P P5.206 % V 84% N % X 14补充背景:怀孕与多发性硬化的减少复发率。首页然而,对潜在的有利影响neuroaxonal变性。光学相干断层扫描(OCT)是一个敏感的、安全的和非侵入性的技术,它提供了histology-like视网膜图像的量化,并允许视网膜神经纤维层厚度(RNFLT)。摘要目的:探讨的潜在影响怀孕在视网膜变性与怀孕和怀孕女性复发汇款女士名RRMS患者。怀孕患者/方法:30和31没有怀孕女性名RRMS患者前瞻性纵向研究。所有患者进行了最新一代光谱域10月(海德堡Spectralis®)和接受神经系统评估连续访问。结果:从1年复发率明显下降,0±0,怀孕之前9 0,6±1、4和0,3±1,1在怀孕中期。在怀孕后期没有复发。临床,有重大变化的高对比度视力(Snellen图表)和整体残疾(eds)与复发无关。RNFL厚度在基线显著低于眼睛的视神经炎(上)相比non-ON眼睛在两组。 Longitudinally, we observed a significant and comparable reduction of the RNFL in both groups (-1,53 µm after 10,2 months in the study and -1,46 µm after 11,7 months in the control group, p<0.05). Conclusion: Despite a clear beneficial effect on relapse rate, pregnancy seems not to have an immediate preventative effect on ongoing neuro-axonal degeneration in RRMS as depicted by OCT retinal imaging.Disclosure: Dr. Schippling has received personal compensation for activities with Novartis. Dr. Schippling has received research support from Bayer Schering and Biogen Idec. Dr. Ayzenberg has nothing to disclose. Dr. Ringelstein has received personal compensation for activities with Novartis. Dr. Aktas has received personal compensation for activities with Bayer, Biogen Idec, Genzyme, Novartis, Teva Neuroscience, and Medimmune as an advisor. Dr. Lukas has nothing to disclose. Dr. Gold has received personal compensation for activities with Bayer HealthCare, Biogen Idec, Merck Serono, Novartis, and Teva Neuroscience. Dr. Hellwig has received personal compensation for activities with Bayer Schering, Biogen Idec, Merck Serono, Teva, Aventis Pharmaceuticals , and Novartis. Dr. Hellwig has received research support from the German Research Foundation.Wednesday, April 22 2015, 2:00 pm-6:30 pm %U