@article {Vahidy398作者= {Farhaan Vahidy和威廉·j·希克斯二世和Indrani Acosta和母鸡Hallevi和回族彭Renganayaki Pandurengan妮可·r·冈萨雷斯和安德鲁·d·Barreto谢丽尔Martin-Schild Tzu-Ching吴和默罕默德·h·拉赫巴尔Arvind b Bambhroliya和詹姆斯·c·Grotta和肖恩。萨维茨},title ={皮质下缺血性中风患者Neurofluctuation},体积={83}={5},页面= {398 - 405}= {2014},doi = {10.1212 / WNL。出版商0000000000000643}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:本研究的目的是评估恶化的发病率,波动,和相关风险对较差的预后结果皮层下中首页风患者(SCS)。方法:我们进行了一项前瞻性研究,招收患者承认SCS基于他们的临床检查和影像学研究。NIH卒中量表评估执行日常检查发现每当恶化。神经功能恶化被定义为一个电动机分数增加至少1在美国国立卫生研究院卒中量表。改良Rankin量表分数在放电被用来评估结果。结果:在90年登记的病人,37(41 \ %)恶化,75 \ %在入学后的第一个24小时。政府组织纤溶酶原激活物能显著恶化(风险比2.25;95 \ %可信区间[CI]: 1.13 {\ textendash} 4.49)甚至在控制了协会与卒中后早期恶化。恶化授予可怜的结果的风险增加(改良Rankin量表得分3 {\ textendash} 6)放电(相对风险:1.80;95 \ % CI: 1.71 1.93 {\ textendash})。降级回predeterioration赤字发生在38 \ %的患者,并与降低放电预后不佳的风险(相对风险:0.12; 95\% CI: 0.02{\textendash}0.83). Treatment with tissue plasminogen activator conferred better chances of spontaneous recovery to predeterioration deficits after initial deterioration (hazard ratio: 4.36; 95\% CI: 1.36{\textendash}14.01).Conclusion: More than 40\% of patients with SCS deteriorate neurologically. Deterioration tends to occur early after stroke, spontaneously reverses in approximately one-third of cases, and poses an increased risk of poor outcome. Therapies are needed to prevent, arrest, or reverse deterioration in patients with SCS.CI=confidence interval; HR=hazard ratio; IQR=interquartile range; m-NIHSS=motor component of the NIH Stroke Scale; mRS=modified Rankin Scale; ND=neurologic deterioration; NIHSS=NIH Stroke Scale; SCS=subcortical stroke; tPA=tissue plasminogen activator}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/83/5/398}, eprint = {//www.ez-admanager.com/content/83/5/398.full.pdf}, journal = {Neurology} }