TY - T1的时间可能不完全减弱solvent-associated认知赤字高暴露工人JF -神经学乔-神经病学SP - 1716 LP - 1723 - 10.1212 / WNL。首页0000000000000413六世- 82 - 19盟Erika l .安息日盟Laure-Anne古铁雷斯盟卡桑德拉a .奥盟-阿卡纳卡盟海琳Amieva AU -马塞尔·戈德堡盟-玛丽寻非盟-克劳丁Berr Y1 - 2014/05/13 UR - //www.ez-admanager.com/content/82/19/1716.abstract N2 -目的:测试终生职业接触溶剂的影响,以剂量和时间来衡量,对性能在多个认知测试中法国公用事业退休工人。首页方法:共有2143名退休人员在2010年的瞪羚群进行了认知测试。一生中接触氯化溶剂、石油溶剂,苯是评估使用的工作接触矩阵。我们建模的影响一生的溶剂剂量,去年曝光的时间,这些指标的组合认知障碍的风险。结果:百分之三十三的参与者暴露在氯化溶剂,26%和25%苯、石油溶剂。高暴露在溶剂差的认知显著相关;例如,那些高度暴露于氯化溶剂细微精神状态检查损伤的风险(风险比1.18;95%置信区间1.06,1.31),数字符号替换测试(1.54;1.31,1.82),语义流畅性测试(1.33;1.14,1.55),和追踪测试B (1.49;1.25,1.77)。 Retirees at greatest risk for deficits had both high lifetime exposure to solvents and were last exposed 12 to 30 years before testing. Risk was somewhat elevated among those with high lifetime exposure who were last exposed 31 to 50 years before testing. Those with high, recent exposure exhibited impairment in almost all domains, including those not typically associated with solvent exposure.Conclusions: While risk of cognitive impairment among moderately exposed workers may attenuate with time, this may not be fully true for those with higher exposure. This has implications for physicians working with formerly solvent-exposed patients as well as for workplace exposure limit policies.BMI=body mass index; CI=confidence interval; DSST=Digit Symbol Substitution Test; EDF-GDF=Electricite de France–Gaz de France; FCSRT=Free and Cued Selective Reminding Test; JEM=job exposure matrix; MMSE=Mini-Mental State Examination; TMT=Trail Making Test ER -