RT期刊文章SR电子T1时间可能不完全减弱solvent-associated认知赤字高暴露工人乔摩根富林明神经病学神经病学FD Lippincott Williams &威尔金斯SP 1716 OP 1723 10.1212 / WNL。首页82签证官0000000000000413 19岁A1 Erika l .安息日A1 Laure-Anne古铁雷斯A1卡桑德拉a奥A1阿卡纳卡A1 Helene Amieva A1马塞尔·戈德堡A1玛丽寻A1克劳丁Berr年2014 UL //www.ez-admanager.com/content/82/19/1716.abstract AB目的:测试终生职业接触溶剂的影响,以剂量和时间来衡量,对性能在多个认知测试首页中法国公用事业退休工人。方法:共有2143名退休人员在2010年的瞪羚群进行了认知测试。一生中接触氯化溶剂、石油溶剂,苯是评估使用的工作接触矩阵。我们建模的影响一生的溶剂剂量,去年曝光的时间,这些指标的组合认知障碍的风险。结果:百分之三十三的参与者暴露在氯化溶剂,26%和25%苯、石油溶剂。高暴露在溶剂差的认知显著相关;例如,那些高度暴露于氯化溶剂细微精神状态检查损伤的风险(风险比1.18;95%置信区间1.06,1.31),数字符号替换测试(1.54;1.31,1.82),语义流畅性测试(1.33;1.14,1.55),和追踪测试B (1.49;1.25,1.77)。 Retirees at greatest risk for deficits had both high lifetime exposure to solvents and were last exposed 12 to 30 years before testing. Risk was somewhat elevated among those with high lifetime exposure who were last exposed 31 to 50 years before testing. Those with high, recent exposure exhibited impairment in almost all domains, including those not typically associated with solvent exposure.Conclusions: While risk of cognitive impairment among moderately exposed workers may attenuate with time, this may not be fully true for those with higher exposure. This has implications for physicians working with formerly solvent-exposed patients as well as for workplace exposure limit policies.BMI=body mass index; CI=confidence interval; DSST=Digit Symbol Substitution Test; EDF-GDF=Electricite de France–Gaz de France; FCSRT=Free and Cued Selective Reminding Test; JEM=job exposure matrix; MMSE=Mini-Mental State Examination; TMT=Trail Making Test

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