RT期刊文章SR电子T1口服抗凝疗法与脑有关Microbleeds (i2 - 2.001)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP i2 - 2.001签证官82是10补充A1 Salo首页ua Akoudad A1泽Darweesh A1 Maarten利恩A1彼得Koudstaal A1阿尔伯特·霍夫曼A1 Aad Van Der卢格特曾A1布鲁诺斯特里克A1穆罕默德伊A1 Meike Vernooij年2014 UL //www.ez-admanager.com/content/82/10_Supplement/I2-2.001.abstract AB目的:探讨口服抗凝疗法(OAT)是否与脑Microbleeds患病率和发病率更高。此外,调查是否最大国际标准化比率(INR)值和可变性INR燕麦用户与microbleeds的存在。背景:燕麦是广泛用于治疗血栓栓塞疾病患者,但也是一个已知的颅内出血的危险因素。脑microbleeds被认为是标记容易出血的血管,和他们的存在会增加颅内出血的风险。它仍未确定是否OAT是亚临床microbleeds一般人群的危险因素。鹿特丹的方法:基于人群的研究门诊口服抗凝药物使用信息从自动化药房记录。OAT用户监测区域中抗凝诊所,和INR值测定在连续访问。为每个参与者的最高测量INR值评估。连续INR值被用来计算在INR可变性。的存在和位置microbleeds额定在大脑的磁共振成像。 A total of 4945 participants aged 45 years and over were included in the cross-sectional analysis. Of these, 831 follow-up examinations were available for longitudinal analysis. We used logistic regression, adjusting for age, sex and cardiovascular risk to investigate the association of OAT with prevalent and incident microbleeds. Results: OAT users had a higher prevalence (age and sex adjusted odds ratio 1.70, 95% CI 1.24-2.34) and incidence (odds ratio 2.53, 95% CI 1.09-5.85) of deep or infratentorial microbleeds compared to never-users. Among anticoagulant drug users, higher maximum INR values and a greater variability in INR was related to a higher prevalence of microbleeds. Conclusions: OAT relates to both prevalent and incident microbleeds. Furthermore, maximum INR values and variability in INR are risk factors for microbleeds, particularly deep or infratentorial microbleeds. Study Supported by: Erasmus Medical Center;Research Institute for Diseases in the Elderly;Ministry of Education, Health,Welfare and Sports.Disclosure: Dr. Akoudad has nothing to disclose. Dr. Darweesh has nothing to disclose. Dr. Leening has nothing to disclose. Dr. Koudstaal has nothing to disclose. Dr. Hofman has received personal compensation in an editorial capacity for the European Journal of Epidemiology. Dr. Van Der Lugt has nothing to disclose. Dr. Stricker has nothing to disclose. Dr. Ikram has nothing to disclose. Dr. Vernooij has nothing to disclose.Sunday, April 27 2014, 1:00 pm-5:00 pm