@article {MitsisP6.323作者={埃菲Mitsis和西尔瓦娜里吉奥和艾米丽D {\ textquoteright}安东尼奥和马丁•戈尔茨坦和史蒂文DeKosky和托马斯·德尔曼Naidich和布拉德利和约瑟夫Machac拉尔Kostakoglu和格雷戈里老人和玛丽佐撒母耳铁路工人和韦恩·戈登},title = {Florbetapir扫描排除{\ textquoteright}年代老年痴呆症与延迟退休NFL球员认知障碍(P6.323)},体积={82}={10}补充数量,elocation-id = {P6.323} ={2014},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们试图确定[18 f] Florbetapir PET成像在NFL球员老龄化澄清诊断认知衰退。首页背景:单一严重创伤性脑损伤(TBI)据信{\ textquoteright}年代老年痴呆症的风险增加(广告),而慢性重复性的创伤性脑损伤的拳击手被认为增加tangle-only疾病的风险,或tauopathy,称为员痴呆(DP)。DP-like病理学已观察到退休NFL球员和退伍军人暴露在爆炸中术语慢性创伤性脑病(CTE)。AD的临床区别于其他的原因我们项{\ textquotedblleft}延迟创伤后认知障碍(DPTCI) {\ textquotedblright}是挑战,但准确的诊断是需要避免在试验包括无脑淀粉样变性者Aβ-reducing代理。设计/方法:一位退休的NFL球员是进行性认知障碍的评估。在他10年的职业生涯中在1960年代- 1970年代,病人报告经历多个脑震荡。由十二个小时赛后,他有时无法名字哪个队他刚刚打了。神经心理测试显示受损的信息处理速度、语言理解能力受损,受损的直接和延迟回忆但智力功能和学习能力保留。一个NFL神经护理项目团队——由一个神经学家,neurologist-psychiatrist,神经心理学家,两个神经放射,评估病人。结果:所有评估者同意的诊断可能DPTCI,但他们无法达成一致可能包含的广告。两个独立的神经心理学家的自抗扰控制器进行测试结果和支持包含可能的广告,虽然主要的研究团队(除了一个神经学家)反对将可能的广告。Florbetapir扫描排除脑淀粉样变性,从而排除广告,病人被诊断为DPTCI没有与可能的CTE淀粉样变。 CONCLUSIONS: This case illustrates the potential for brain amyloid imaging to prevent the inappropriate inclusion of non-AD patients (including those with a history of TBI) in trials of Aβ-reducing agents.Disclosure: Dr. Mitsis has nothing to disclose. Dr. Riggio has nothing to disclose. Dr. D{\textquoteright}Antonio has nothing to disclose. Dr. Goldstein has nothing to disclose. Dr. DeKosky has received personal compensation in an editorial capacity for UpToDate. Dr. Naidich has nothing to disclose. Dr. Delman has nothing to disclose. Dr. Machac has nothing to disclose. Dr. Kostakoglu has nothing to disclose. Dr. Elder has nothing to disclose. Dr. Sano has received personal compensation for activities with Aventis Pharmaceuticals Inc., Bayer Pharmaceutical Corp., Forest Laboratories Inc., GlaxoSmithKline Inc., Janssen, Medication, Bristol-Myer Squibb Co., OrthoMcNeil, and Takeda. Dr. Gandy has received personal compensation for activities with Johnson \& Johnson, Pfizer Inc, Alzheimer Immunotherapy Alliance, Diagenic, Amicus, and Baxter. Dr. Gordon has nothing to disclose.Thursday, May 1 2014, 7:30 am-11:00 am}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/82/10_Supplement/P6.323}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }