TY -的T1 -淀粉样的实际效用和正子在学术痴呆中心JF -神经学乔-神经病学SP - 230 LP - 238 - 10.1212 / WNL。首页0000000000000032六世盟- 82 - 3 -帕斯卡Sanchez-Juan盟Pia m . Ghosh盟杰恩Hagen盟玛雅亨利- b Gesierich盟盟- Lea t·格林贝格盟詹姆斯p奥尼尔AU -穆斯塔法Janabi AU -埃里克·j·黄盟-约翰问:Trojanowski AU -哈利诉Vinters盟Marilu Gorno-Tempini AU -威廉·w·斯利盟亚当·l·拳击手AU -霍华德·j·罗森盟乔尔·h·克雷默AU -布鲁斯·l·米勒盟William j . Jagust AU -吉尔·d·Rabinovici Y1 - 2014/01/21 UR - //www.ez-admanager.com/content/82/3/230.abstract N2 -目的:评价淀粉样蛋白成像临床决策的影响。首页方法:我们进行了一项回顾性分析140认知障碍患者(平均年龄65.0岁,46%主要β-amyloid (Aβ)诊断、细微精神状态检查平均22.3)接受淀粉样蛋白(匹兹堡化合物B[加以])宠物作为观察研究的一部分,研究和评价临床之前和之后的扫描。一百三十四年同时接受氟脱氧葡萄糖(FDG) pet。我们评估之间的变化和post-PET临床诊断(从Aβnon-Aβ诊断,反之亦然)和阿尔茨海默病的治疗计划。之间的关系加以/ FDG结果和变化管理评估使用χ2和多元逻辑回归。后期诊断可供24例(17%)。结果:扫描结果之间的一致性和基线诊断高(加以84%,前82%)。初步诊断后改变了宠物在13/140例(9%)整体但在5/13(38%)的患者认为pre-PET诊断困境。当独立检查,不和谐的加以相关和不和谐的配合都是诊断改变(未调整p & lt;0.0001)。 However, when examined together in a multivariate logistic regression, only discordant PiB remained significant (adjusted p = 0.00013). Changes in treatment were associated with discordant PiB in patients with non-Aβ diagnoses (adjusted p = 0.028), while FDG had no effect on therapy. Both PiB (96%) and FDG (91%) showed high agreement with autopsy diagnosis.Conclusions: PET had a moderate effect on clinical outcomes. Discordant PiB had a greater effect than discordant FDG, and influence on diagnosis was greater than on treatment. Prospective studies are needed to better characterize the clinical role of amyloid PET.Aβ=β-amyloid; AD=Alzheimer disease; AUC=appropriate use criteria; CBS=corticobasal syndrome; CDR=Clinical Dementia Rating; Che-I=cholinesterase inhibitor; CMS=Centers for Medicare & Medicaid Services; DLB=dementia with Lewy bodies; FDG=fluorodeoxyglucose; FTD=frontotemporal dementia; MCI=mild cognitive impairment; PiB=Pittsburgh compound B; UCSF=University of California, San Francisco ER -