泰在MRI的T1 -白质hyperintensities高空u - 2侦察机飞行员JF -神经学乔-神经病学SP - 729 LP - 735 - 10.1212 / W首页NL。0 b013e3182a1ab12六世- 81 - 8 AU -斯蒂芬·麦奎尔盟-保罗·谢尔曼AU -莱昂纳多Profenna AU -帕特里克·甘盟约翰Sladky AU -安东尼布朗AU -安德鲁·罗宾逊AU -劳拉·罗兰AU -艾略特香港盟Beenish Patel盟-大卫·泰特盟-伊莱恩·s .【盟-彼得·福克斯盟-彼得Kochunov Y1 - 2013/08/20 UR - //www.ez-admanager.com/content/81/8/729.abstract N2 -目的:证明u - 2侦察机飞行员职业接触hypobaria导致发病率增加白质hyperintensities(负责人)更均匀分布在整个大脑无论临床神经减压病的历史首页。方法:我们在102年评估影像学表现u - 2侦察机飞行员和91名对照匹配年龄、健康和教育水平。三维、t2加权高分辨率(1毫米各向同性)成像数据收集使用fluid-attenuated反转恢复序列3-tesla MRI扫描仪。整个大脑和区域负责人体积和数量比较组间使用2-tailed Wilcoxon等级和测试。结果:u - 2侦察机飞行员显示体积的增加(394%;p = 0.004)和数字(295%;p < 0.001) of WMH. Analysis of regional distribution demonstrated WMH more uniformly distributed throughout the brain in U-2 pilots compared with mainly frontal distribution in controls.Conclusion: Pilots with occupational exposure to hypobaria showed a significant increase in WMH lesion volume and number. Unlike the healthy controls with predominantly WMH in the frontal white matter, WMH in pilots were more uniformly distributed throughout the brain. This is consistent with our hypothesized pattern of damage produced by interaction between microemboli and cerebral tissue, leading to thrombosis, coagulation, inflammation, and/or activation of innate immune response, although further studies will be necessary to clarify the pathologic mechanisms responsible.BET=brain extraction tool; DCS=decompression sickness; FLAIR=fluid-attenuated inversion recovery; FMRIB=Functional MRI of the Brain; NDCS=neurologic decompression sickness; RF=radiofrequency; 3D=3-dimensional; USAF=United States Air Force; WMH=white matter hyperintensities ER -