TY - T1的不宁腿综合症和白天嗜睡是突出在肌强直性营养不良2型JF -神经学乔-神经病学SP - 157 LP - 164 - 10.1212 / WNL。首页0 b013e31829a340f六世- 81 - 2非盟-艾瑞克·m·林盟——保罗·w·谢泼德盟——埃里克·k·圣路易斯盟-卢卡斯g . Dueffert AU -南希Slocumb盟-斯图亚特·j·迈克AU -迈克尔·h·西尔柏盟布拉德利f . Boeve AU -埃里克·j·奥尔森盟Virend k·萨默斯AU -玛格丽塔Milone Y1 - 2013/07/09 UR - //www.ez-admanager.com/content/81/2/157.abstract N2 -目的:尽管睡眠障碍是常见的肌强直性营养不良1型(DM1)、肌强直性营养不良的睡眠障碍2型(DM2)尚未特首页征明显。我们旨在确定睡眠障碍在DM2的频率。54基因的方法:我们进行了一项病例对照研究证实DM2主题和104名医疗控制没有DM1或DM2,和调查常见的睡眠障碍,包括可能的不宁腿综合症的症状(RLS),日间极度嗜睡(EDS)、睡眠质量、疲劳、阻塞性睡眠呼吸暂停(OSA),可能的REM睡眠行为障碍(pRBD),和痛苦。三十DM2患者和43控制对调查作出回应。集团与参数统计检验和多元线性和逻辑回归分析的因变量进行EDS和糟糕的睡眠质量。结果:DM2和控制患者的平均年龄分别为63.8和64.5年,分别。Significant sleep disturbances in patients with DM2 compared to controls included probable RLS (60.0% vs 14.0%, p < 0.0001), EDS (p < 0.001), sleep quality (p = 0.02), and fatigue (p < 0.0001). EDS and fatigue symptoms were independently associated with DM2 diagnosis (p < 0.01) after controlling for age, sex, RLS, and pain scores. There were no group differences in OSA (p = 0.87) or pRBD (p = 0.12) scores.Conclusions: RLS, EDS, and fatigue are frequent sleep disturbances in patients with DM2, while OSA and pRBD symptoms are not. EDS was independently associated with DM2 diagnosis, suggesting possible primary CNS hypersomnia mechanisms. Further studies utilizing objective sleep measures are needed to better characterize sleep comorbidities in DM2.DM1=myotonic dystrophy type 1; DM2=myotonic dystrophy type 2; DSS=Daytime Sleepiness Scale; EDS=excessive daytime sleepiness; ESS=Epworth Sleepiness Scale; FSS=Fatigue Severity Scale; MSQ=Mayo Sleep Questionnaire; OSA=obstructive sleep apnea; pRBD=probable REM sleep behavior disorder; PSQI=Pittsburgh Sleep Quality Index; RBD=REM sleep behavior disorder; RLS=restless legs syndrome; SA-SDQ=Sleep Apnea scale of the Sleep Disorders Questionnaire ER -