TY - T1的MRI和夫人预测轻度认知障碍的人群为基础的样本JF -神经学乔-神经病学SP - 126 LP - 133 - 10.1212 / WNL。首页0 b013e31829a3329六世- 81 - 2非盟- Kejal Kantarci盟——斯蒂芬·d·Weigand AU -斯科特·a·Przybelski盟Gregory m . Preboske AU - v . Shane Pankratz说道盟Prashanthi Vemuri AU -马修·l·Senjem AU -马修·c·墨菲盟Jeffrey l .甘特盟-玛丽·m·Machulda盟Robert j . Ivnik AU -玫瑰花蕾o·罗伯茨盟布拉德利f . Boeve AU -沃尔特·a·罗卡盟David s . Knopman AU -罗纳德·c·彼得森AU -克利福德·r·杰克,小Y1 - 2013/07/09 UR - //www.ez-admanager.com/content/81/2/126.abstract N2 -目的:探讨质子磁共振成像和磁共振光谱学(夫人)预测轻度认知障碍(MCI)在认知正常的老年人。首页方法:受试者(n = 1156)认知正常的老年人参与衰老的人群梅奥诊所研究MRI /夫人研究从2005年8月到2010年12月,至少一年的临床随访。Single-voxel后扣带脑回了夫人,和海马卷卷和白质高密度量化使用自动化的方法。脑梗塞在MRI评估。Cox比例风险回归,随着年龄的增长随着时间尺度,被用来评估MRI和标记夫人的影响发展的风险认知正常MCI。线性mixed-effects模型被用来评估MRI和夫人标记的影响认知能力下降。结果:后平均2.8年的随访中,214名参与者已经发展到MCI或痴呆(估计发病率= 6.1%;95%置信区间为5.3% - -7.0%)。在单变量建模中,海马体积,白质hyperintensity体积,N-acetylaspartate /肌醇在认知正常的老年人MCI的重要预测因子。在多变量模型中,只有减少海马体积和N-acetylaspartate /肌醇是MCI的独立预测指标。 These MRI/MRS predictors of MCI as well as infarcts were associated with cognitive decline (p < 0.05).Conclusion: Quantitative MRI and MRS markers predict progression to MCI and cognitive decline in cognitively normal older adults. MRS may contribute to the assessment of preclinical dementia pathologies by capturing neurodegenerative changes that are not detected by hippocampal volumetry.AD=Alzheimer disease; Cr=creatine; DSM-III-R=Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised; FDG=18F-fluorodeoxyglucose; FLAIR=fluid-attenuated inversion recovery; 1H-MRS=proton magnetic resonance spectroscopy; HR=hazard ratio; IQR=interquartile range; MCI=mild cognitive impairment; MCSA=Mayo Clinic Study of Aging; mI=myo-inositol; MRS=magnetic resonance spectroscopy; NAA=N-acetylaspartate; TIV=total intracranial volume; WM=white matter; WMH=white matter hyperintensity ER -