TY - T1的前瞻性研究的不宁腿综合症和死亡率男性JF -神经学乔-神经病学SP - 52 LP - 59 - 10.1212 / WNL。首页0 b013e318297eee0六世- 81 - 1 AU王伟(音译)-砚李盟盟——约翰·w·温克曼主持盟Atul Malhotra AU -马京盟香高Y1 - 2013/07/02 UR - //www.ez-admanager.com/content/81/1/52.abstract N2 -目的:前瞻性研究是否男人首页不宁腿综合症(RLS)的风险增加死亡率。方法:这是一个前瞻性队列研究的18425名美国人自由的糖尿病,关节炎和肾功能衰竭的卫生专业人员随访研究(HPFS分区)。2002年,RLS是评估使用一组标准化的问题。死亡是从国家至关重要的数据记录,确定全国死亡指数、家庭报告,和邮政系统。结果:在8年的随访(2002 - 2010),我们记录了2765人死亡。在一个年龄调整模型,RLS是死亡的风险增加39%(危险比[HR] = 1.39;95%可信区间[CI] 1.19 - -1.62;p & lt;0.0001)。RLS和死亡率之间的关系略减毒后进一步调整体重指数、生活方式因素,慢性疾病,睡眠时间,和其他睡眠障碍(调整HR = 1.30;95%可信区间1.11 - -1.52; p = 0.003). When we further excluded those with major chronic conditions (e.g., cancer, high blood pressure, cardiovascular disease, and other comorbidities), the adjusted HR was 1.92 (95% CI 1.03–3.56; p = 0.04). The interactions between RLS and other risk factors (older age, overweight, short sleep duration, smoking, low physical activity, and unhealthy diet) in relation to total mortality risk were not significant (p for interaction >0.2 for all).Conclusion: We observed that men with RLS had a higher overall mortality and this association was independent of known risk factors. The increased mortality in RLS was more frequently associated with respiratory disease, endocrine disease, nutritional/metabolic disease, and immunologic disorders. Future research exploring the pathophysiologic relationship between these disorders and RLS is warranted.AHEI=Alternate Healthy Eating Index; BMI=body mass index; CI=confidence interval; CVD=cardiovascular disease; HPFS=Health Professionals Follow-up Study; HR=hazard ratio; ICD-8=International Classification of Diseases, eighth revision; IRLSSG=International RLS Study Group; MS=multiple sclerosis; PD=Parkinson disease; PLMS=periodic limb movements of sleep; RLS=restless legs syndrome ER -