TY -的T1 -海马发作癫痫样的人类活动破坏认知JF -神经学乔-神经病学SP - 18 LP - 24 - 10.1212 / WNL。首页0 b013e318297ee50六世- 81 - 1 AU -乔纳森·k·克林盟格里高利·赫尔姆斯-杆c . Scott盟盟-大卫·w·罗伯茨盟梅丽莎·m·梯级AU -马库斯Testorf盟Pierre-Pascal Lenck-Santini盟——芭芭拉·c·Jobst Y1 - 2013/07/02 UR - //www.ez-admanager.com/content/81/1/18.abstract N2 -目的:我们研究是否发作癫痫样的排放(IED)在人类海马损伤相关的特定记首页忆的过程,而海马简易爆炸装置的特点是最与记忆功能障碍有关。方法:10例植入了深度电极对术前的海马癫痫本地化。脑电图记录在2070年的总试验短时记忆任务时,内存处理分为编码,维护和检索。海马IED在这些过程的影响进行了分析和调整,以占病人之间的个体差异。Results: Hippocampal IED occurring in the memory retrieval period decreased the likelihood of a correct response when they were contralateral to the seizure focus (p < 0.05) or bilateral (p < 0.001). Bilateral IED during the memory maintenance period had a similar effect (p < 0.01), particularly with spike-wave complexes of longer duration (p < 0.01). IED during encoding had no effect, and reaction time was also unaffected by IED.Conclusions: Hippocampal IED in humans may disrupt memory maintenance and retrieval, but not encoding. The particular effects of bilateral IED and those contralateral to the seizure focus may relate to neural compensation in the more functional hemisphere. This study provides biological validity to animal models in the study of IED-related transient cognitive impairment. Moreover, it strengthens the argument that IED may contribute to cognitive impairment in epilepsy depending upon when and where they occur.CI=confidence interval; DMTS=delayed-match-to-sample task; GEE=generalized estimating equations; IAT=intracarotid amobarbital testing; IED=interictal epileptiform discharges; OR=odds ratio; TLE=temporal lobe epilepsy ER -