TY - T1的皮质病变亚型的贡献在7 t MRI在摩根富林明女士身体和认知能力——神经学乔-神经病学SP - 641 LP - 649 - 10.1212 / WNL。首页0 b013e3182a08ce8六世- 81 - 7盟——a·斯科特·尼尔森盟敬畏p Kinkel盟——南希·马迪根盟Emanuele Tinelli AU -托马斯Benner盟Caterina Mainero Y1 - 2013/08/13 UR - //www.ez-admanager.com/content/81/7/641.abstract N2 -目的:评价横首页向比较的贡献焦皮质病变(CL)亚型ultra-high-field MRI和传统MRI度量脑损伤的神经系统残疾和认知能力在异构多发性硬化症(MS)队列。方法:34例早期或建立疾病包括临床孤立综合征、复发缓和女士,女士和次要进步扫描在人类7-tesla (7 t)(西门子)扫描仪获取快速低角拍摄(FLASH) T2 *三图片描述病变深白质和灰质体积,和CL类型。患者还进行了解剖3 t MRI皮质厚度估计,1周内和神经心理学测试7 t扫描。27个病人接受了扫描进一步分析。神经系统残疾用扩大残疾状态量表测量。结果:类型iii iv CLs有强烈关系身体残疾(ρ= 0.670,p & lt;0.0001)。白质病变体积和I型CLs都6 11神经心理学测试变量显著相关。类型iii iv CLs明显与4 11神经心理学测试变量而II型CLs,深灰质体积损伤,和皮质厚度指标不太经常与认知能力有关。结论:Leukocortical (I型)和单纯(iii iv) 7日CLs确定t FLASH-T2 *序列是潜在的认知和神经皮质生物标志物在MS.ANT =动物命名测试;BDI =贝克抑郁量表,第二版; BVMTR=Brief Visual Memory Test–Revised; CL=cortical lesion; CLR=cortical lesion ratio; COWAT=Controlled Oral Word Association Test; CT=cortical thickness; CVLT2=California Verbal Learning Test, 2nd edition; DGMLV=deep gray matter lesion volume; DIR=double inversion recovery; EDSS=Expanded Disability Status Scale; FLASH=fast low-angle shot; GM=gray matter; JLOT=Judgment of Line Orientation Test; MEMPR=magnetization-prepared rapid acquisition with multiple gradient echoes; MS=multiple sclerosis; NPT=neuropsychological test; SDMT=Symbol Digit Modalities Test; SPMS=secondary progressive multiple sclerosis; WCST=Wisconsin Card Sorting Test–64 card deck; WM=white matter; WMLV=white matter lesion volume; WTAR=Wechsler Test of Adult Reading ER -