% 0期刊文章%丘加尼哈利T %艾梅f . Luat % Ajay Kumar %拉库马Govindan %一个Eishi浅野凯西·鲍里克% % Tα- (11C)甲基-l191年-tryptophan-PET结节性硬化症患者复杂% D R 10.1212 / WNL 2013%。0 b013e3182a08f3f % 首页J神经病学% P 674 - 680 X % V 81% N 7%目标:这是一个观察性研究在一个大型的复杂结节性硬化症(TSC)来确定患者是否存在α- c [11] -methyl-l-tryptophan (AMT)热点与癫痫发作的持续时间难驾驭,ii)的AMT热点与特定的TSC基因突变,和iii)之间存在一致性区域AMT热点和没收的偏侧性/本地化头皮脑电图。方法:一百九十一例患者(平均年龄:6.7岁;中位数:5年;范围:3个月37年)TSC和难治性癫痫是包括在内。所有患者接受AMT-PET扫描。AMT在每个块茎和正常皮质吸收测定与临床相关,头皮脑电图,并且,如果可用,electrocorticographic数据。结果:癫痫棘手的持续时间越长,越AMT热点(r = 0.2;p = 0.03)。AMT热点TSC1和TSC2。癫痫有优秀的协议焦点之间的偏侧性发作的头皮脑电图和AMT-PET科恩(κ0.94)在68年的95例发作性video-EEG和AMT-PET显示使向侧面发现;68年28例(41%),AMT更加本地化。 Furthermore, AMT-PET was localizing in 10 of 17 patients (58%) with nonlateralized ictal EEG.Conclusion: AMT-PET, when used together with video-EEG, provides additional lateralization/localization data, regardless of TSC mutation. The duration of seizure intractability may predict the multiplicity of areas with AMT hotspots.AMT=α-[11C]-methyl-l-tryptophan; ECoG=electrocorticographic; FDG=2-deoxy-2-(18F)fluoro-d-glucose; FLAIR=fluid-attenuated inversion recovery; TSC=tuberous sclerosis complex %U //www.ez-admanager.com/content/neurology/81/7/674.full.pdf