@article {Charidimou626作者= {Andreas Charidimou Rolf汉斯·J{\”}蒙古包和佐伊福克斯和安德烈·彼得斯和伊夫Vandermeeren帕特里斯·Laloux特里男爵和大卫•约翰回答}title ={的皮质表面铁尘肺患病率和机制脑淀粉样血管病},体积={81}={7},页面= {626 - 632}= {2013},doi = {10.1212 / WNL。出版商0 b013e3182a08f2c} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们调查的患病率和clinical-radiologic协会皮质表面首页铁尘肺患者(cSS)可能脑淀粉样血管病(CAA)相比脑出血(我)不属于创新艺人经纪公司。方法:我们对120例患者进行了回顾性多中心队列研究可能的创新艺人经纪公司,比较2组:67例单一大叶性我或混合(深,大叶性)出血;患者和22严格深出血。我,我们额定cSS白质变化,脑microbleeds。结果:cSS中检测出48 120 (40 \ %;95 \ %可信区间[CI]: 31.2 \ % 49.3 {\ textendash} \ %)患者可能的创新艺人经纪公司,67年10 (14.9 \ %;95 \ % CI: 7.4 \ % 25.7 {\ textendash} \ %)与单一的大叶性我或混合出血,22日和1 (4.6 \ %;95 \ % CI: 0.1 \ % 22.8 {\ textendash} \ %)患者严格深出血(趋势p \ < 0.001)。传播cSS在场120年29日(24 \ %;95 \ % CI: 16.8 \ % 32.8 {\ textendash} \ %)患者可能的创新艺人经纪公司,但是我没有其他的患者(p < 0.001)。在可能的创新艺人经纪公司,年龄(优势比[或]:1.09;95 \ % CI: 1.03 {\ textendash} 1.15; p = 0.002), chronic lobar ICH (OR: 3.94; 95\% CI: 1.54{\textendash}10.08; p = 0.004), and a history of transient focal neurologic episodes (OR: 11.08; 95\% CI: 3.49{\textendash}35.19; p \< 0.001) were independently associated with cSS. However, cSS occurred in 17 of 48 patients with probable CAA (35.4\%; 95\% CI: 22.2\%{\textendash}50.5\%) without chronic lobar ICH.Conclusions: cSS (particularly if disseminated) is a common and characteristic feature of CAA. Chronic lobar ICH is an independent risk factor for cSS, but the causal direction and mechanism of association are uncertain. Hemorrhage into the subarachnoid space, independent of previous (chronic) lobar ICH, must also contribute to cSS in CAA. Transient focal neurologic episodes are the strongest clinical marker of cSS.CAA=cerebral amyloid angiopathy; CI=confidence interval; CMB=cerebral microbleed; cSAH=convexity subarachnoid hemorrhage; cSS=cortical superficial siderosis; FLAIR=fluid-attenuated inversion recovery; ICH=intracerebral hemorrhage; OR=odds ratio; T2*-GRE=T2*-weighted gradient recalled echo}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/81/7/626}, eprint = {//www.ez-admanager.com/content/81/7/626.full.pdf}, journal = {Neurology} }