RT期刊文章SR电子T1谢谢机械血栓切除术用于治疗急性缺血性中风的猎犬摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP S126 OP S134 10.1212 / WNL。首页0 b013e3182697e89 VO 79是13补充1 A1 Amer Alshekhlee A1 Dhruvil j·迪亚A1乔伊英语A1奥萨马o . Zaidat A1尼尔斯·穆勒A1圣人Gupta A1劳尔•g . Nogueira年2012 UL //www.ez-admanager.com/content/79/13_Supplement_1/S126.abs首页tract AB背景:机械血栓切除术是一种很有前途的辅助或独立治疗急性缺血性中风(AIS)引起的大血管闭塞患者在全身溶栓治疗窗口。本文着重于机械血栓切除术的临床和血管造影结果谢谢寻回犬的使用设备。方法:可用的文学出版日期的主要试验和观察性研究涉及谢谢寻回犬了。除了复习,结果研究涉及谢谢寻回犬相比,结果在急性脑Prolyse血栓II (PROACT II)和半影设备研究。良好的预测结果后血管再生与谢谢设备的基础上,综述了出版分层分析。良好的临床结果被改良Rankin谢谢经验中定义的规模(夫人)评分≤2 AIS后90天。结果:综述介绍共有1226名患者接受谢谢设备;305名患者来自2涉及关键试验设备,和其余的921名患者的观察性研究谢谢注册表。≤2的90天的夫人在32%的病人组中,实现了整体死亡率为35.2%。 Symptomatic intracerebral hemorrhage was identified in 7.3% of patients treated with Merci retriever, a result comparable to that in the PROACT II and Penumbra thrombectomy trials. Successful recanalization, lower NIH Stroke Scale score, and younger age were identified as the strongest predictors of favorable outcomes. Conclusion: Mechanical thrombectomy with the Merci retriever device is a safe treatment modality for AIS patients presenting with a large-vessel occlusion within 8 hours of symptom onset. Although the Merci retriever showed a good recanalization rate, there are currently no randomized clinical trials to assess its clinical efficacy in comparison with systemic thrombolysis within a window of 3 to 4.5 hours or with standard of care beyond a 4.5-hour window. AIS=acute ischemic stroke; CI=confidence interval; IA-tPA=intra-arterial tissue plasminogen activator; ICH=intracerebral hemorrhage; IV-tPA=IV tissue plasminogen activator; MERCI=Mechanical Embolus Removal in Cerebral Ischemia; mRS=modified Rankin Scale; NIHSS=NIH Stroke Scale; OR=odds ratio; PROACT=Prolyse in Acute Cerebral Thromboembolism; TICI=thrombolysis in cerebral infarction; TIMI=thrombolysis in myocardial infarction