RT期刊文章SR电子T1葡萄糖代谢,灰质结构、主观记忆障碍和记忆下降摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 1332 OP 1339 10.1212 / WNL。首页0 b013e31826c1a8d VO 79是13 A1卢卡斯Scheef A1安妮卡Spottke A1莫里茨Daerr A1科乔A1 Nadine Striepens A1 Heike Kolsch A1朱利叶斯Popp来说A1 Marcel Daamen A1杜米尼克Gorris A1 Michael t . Heneka A1亨宁Boecker A1汉斯·j·Biersack A1沃尔夫冈·迈尔A1汉斯·h·席尔德A1迈克尔·瓦格纳A1弗兰克安杰森年2012 UL //www.ez-admanager.com/content/79/13/1332.abstract AB目的:识别生物证据的阿尔茨海默病(AD)患者主观记忆障碍(SMI)和未受损首页伤的认知表现和探讨纵向认知课程在这些科目。方法:[18 f] fluoro-2-deoxyglucose宠物(正)和结构磁共振成像获得31个学科与重度和56个控件。认知执行后续的测试(平均随访时间:35个月)。差异在基线脑成像数据和记忆衰退评估两组之间。联想记忆衰退的脑成像数据进行了测试。结果:重度组显示在右侧楔前叶代谢减退,代谢亢进正确的内侧颞叶。灰质体积减少正确的海马体在重度精神病患者。在随访中,受试者与重度显示性能降低情景记忆的控制措施。重度组纵向记忆衰退,减少葡萄糖代谢在右侧楔前叶基线。 Conclusion: The cross-sectional difference in 2 independent neuroimaging modalities indicates early AD pathology in SMI. The poorer memory performance at follow-up and the association of reduced longitudinal memory performance with hypometabolism in the precuneus at baseline support the concept of SMI as the earliest manifestation of AD. AD=Alzheimer disease; AUC=area under the curve; BDI=Beck Depression Inventory; CERAD=Consortium to Establish a Registry for Alzheimer's Disease; CI=confidence interval; FDG-PET=[18F]fluoro-2-deoxyglucose PET; FWE=family-wise error; GM=gray matter; MCI=mild cognitive impairment; rCGM=regional cerebral glucose metabolism; ROC=receiver operating characteristic; ROI=region of interest; SCID=Structured Clinical Interview for DSM-IV; SMI=subjective memory impairment; SVC=small volume correction; TMT=Trail-Making Test; VLMT=Verbal Learning and Memory Test; WM=white matter

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