% 0期刊文章%一个安妮卡Spottke卢卡斯Scheef % %一科乔莫里茨Daerr % %一个Nadine Striepens % Heike Kolsch %朱利叶斯Popp来说%一个杜米尼克Gorris Marcel Daamen % %一个迈克尔·T·Heneka % Boecker亨宁%汉斯·j·Biersack席尔德%一个汉斯·h·沃尔夫冈·迈尔% %迈克尔·瓦格纳% %弗兰克安杰森T葡萄糖代谢,灰质结构、主观记忆障碍和记忆下降% D R 10.1212 / WNL 2012%。0 b013e31826c1a8d % 首页J神经病学% P 1332 - 1339 X % V 79% N 13%目的:识别生物证据的阿尔茨海默病(AD)患者主观记忆障碍(SMI)和未受损伤的认知表现和探讨纵向认知课程在这些科目。方法:[18 f] fluoro-2-deoxyglucose宠物(正)和结构磁共振成像获得31个学科与重度和56个控件。认知执行后续的测试(平均随访时间:35个月)。差异在基线脑成像数据和记忆衰退评估两组之间。联想记忆衰退的脑成像数据进行了测试。结果:重度组显示在右侧楔前叶代谢减退,代谢亢进正确的内侧颞叶。灰质体积减少正确的海马体在重度精神病患者。在随访中,受试者与重度显示性能降低情景记忆的控制措施。重度组纵向记忆衰退,减少葡萄糖代谢在右侧楔前叶基线。结论:横断面差异2独立神经成像模式表明重度精神病的早期AD病理。 The poorer memory performance at follow-up and the association of reduced longitudinal memory performance with hypometabolism in the precuneus at baseline support the concept of SMI as the earliest manifestation of AD. AD=Alzheimer disease; AUC=area under the curve; BDI=Beck Depression Inventory; CERAD=Consortium to Establish a Registry for Alzheimer's Disease; CI=confidence interval; FDG-PET=[18F]fluoro-2-deoxyglucose PET; FWE=family-wise error; GM=gray matter; MCI=mild cognitive impairment; rCGM=regional cerebral glucose metabolism; ROC=receiver operating characteristic; ROI=region of interest; SCID=Structured Clinical Interview for DSM-IV; SMI=subjective memory impairment; SVC=small volume correction; TMT=Trail-Making Test; VLMT=Verbal Learning and Memory Test; WM=white matter %U //www.ez-admanager.com/content/neurology/79/13/1332.full.pdf