@article {Scheef1332作者={卢卡斯Scheef乔和安妮卡Spottke和莫里茨Daerr科Nadine Striepens Heike K {\ " o} lsch和朱利叶斯Popp来说和马塞尔Daamen杜米尼克Gorris和Michael t . Heneka Boecker亨宁和汉斯·j . Biersack沃尔夫冈·迈尔和汉斯·h·席尔德迈克尔·瓦格纳和弗兰克•安杰森}title ={葡萄糖代谢、灰质结构、主观记忆障碍和记忆下降},体积={79}={13},页面= {1332 - 1339}= {2012},doi = {10.1212 / WNL。出版商0 b013e31826c1a8d} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:识别生物证据的阿尔茨海默病(AD)患者主观记忆障碍(SMI)和未受损首页伤的认知表现和探讨纵向认知课程在这些科目。方法:[18 f] fluoro-2-deoxyglucose宠物(正)和结构磁共振成像获得31个学科与重度和56个控件。认知执行后续的测试(平均随访时间:35个月)。差异在基线脑成像数据和记忆衰退评估两组之间。联想记忆衰退的脑成像数据进行了测试。结果:重度组显示在右侧楔前叶代谢减退,代谢亢进正确的内侧颞叶。灰质体积减少正确的海马体在重度精神病患者。在随访中,受试者与重度显示性能降低情景记忆的控制措施。重度组纵向记忆衰退,减少葡萄糖代谢在右侧楔前叶基线。结论:横断面差异2独立神经成像模式表明重度精神病的早期AD病理。 The poorer memory performance at follow-up and the association of reduced longitudinal memory performance with hypometabolism in the precuneus at baseline support the concept of SMI as the earliest manifestation of AD. AD=Alzheimer disease; AUC=area under the curve; BDI=Beck Depression Inventory; CERAD=Consortium to Establish a Registry for Alzheimer{\textquoteright}s Disease; CI=confidence interval; FDG-PET=[18F]fluoro-2-deoxyglucose PET; FWE=family-wise error; GM=gray matter; MCI=mild cognitive impairment; rCGM=regional cerebral glucose metabolism; ROC=receiver operating characteristic; ROI=region of interest; SCID=Structured Clinical Interview for DSM-IV; SMI=subjective memory impairment; SVC=small volume correction; TMT=Trail-Making Test; VLMT=Verbal Learning and Memory Test; WM=white matter}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/79/13/1332}, eprint = {//www.ez-admanager.com/content/79/13/1332.full.pdf}, journal = {Neurology} }