TY -的T1 -焊接协会和锰暴露与帕金森病JF -神经学乔-神经病学SP - 1174 LP - 1180 - 10.1212 / WNL。首页0 b013e3182698ced六世非盟- 79 - 11 -詹姆斯·a·莫蒂默AU -艾米·r·伯伦斯坦盟Lorene m . Nelson Y1 - 2012/09/11 UR - //www.ez-admanager.com/content/79/11/首页1174.abstract N2 -目的:检查焊接协会和锰暴露与帕金森病(PD)利用群体的荟萃分析的数据,病例对照,和死亡率的研究。方法:相关流行病学研究焊接或锰暴露和PD在PubMed搜索发现,文章引用,发表评论,和抽象。入选标准是1)队列、病例对照或死亡率研究相对危险度(RR),比值比(或),或死亡率(铁道部)和95置信区间(95% CI);2)RR,或者和铁道部或调整年龄和性别匹配;3)有效的研究设计和分析。当参与者的一个研究小组的一个更大的研究中,只有更大的研究结果包括确保独立的数据集。汇集RR /或估计,95%的独联体使用随机效应模型得到;异质性的研究效果评估利用Q统计量和I2指数固定效应模型。结果:13研究符合纳入标准的焊接荟萃分析和研究锰暴露荟萃分析。 The pooled RR for the association between welding and PD for all study designs was 0.86 (95% CI 0.80–0.92), with absence of between-study heterogeneity (I2 = 0.0). Effect measures for cohort, case-control, and mortality studies were similar (0.91, 0.82, 0.87). For the association between manganese exposure and PD, the pooled OR was 0.76 (95% CI 0.41–1.42). Conclusions: Welding and manganese exposure are not associated with increased PD risk. Possible explanations for the inverse association between welding and PD include confounding by smoking, healthy worker effect, and hormesis. CI=confidence interval; MOR=mortality odds ratio; OR=odds ratio; PD=Parkinson disease; RR=relative risk ER -