TY - T1的精神障碍在迅速发生dystonia-parkinsonism JF -神经学乔-神经病学SP - 1168 LP - 1173 - 10.12首页12 / WNL。0 b013e3182698d6c六世- 79 - 11 AU -埃里森Brashear盟贾里德·f·库克AU -黛博拉·f·希尔盟阿勒西娅Amponsah AU -贝弗利Snively m . AU兰妮光AU -妮基·博格斯盟辛西娅·k·Suerken AU -马克史黛西AU -劳里Ozelius盟凯萨琳j . Sweadner盟——w·沃恩·考尔Y1 - 2012/09/11 UR - //www.ez-admanager.com/content/79/11/1168.abstract N2 -目的:急性dystonia-parkinsonism (RDP)是由各种各样的错义突变ATP1A3基因。首页精神疾病已经报道,尽管精神疾病的系统检测与RDP缺乏个人。本研究探讨精神病发病率23 RDP患者10家庭与家庭成员对照组和3无关的RDP的患者,共56人。方法:29 ATP1A3 mutation-positive个人检查;26日展出运动症状(电机展现载体(MMC))和3没有(nonmotor展现运营商(NMC))。27 ATP1A3 mutation-negative参与者(非携带者(NC))都包括在内。的心理疾病率RDP和相关的无症状患者的基因突变携带者与相关nonmutation运营商比较。结果评价包括统一帕金森病评定量表,Burke-Fahn-Marsden肌张力障碍评定量表,工具性日常生活活动,复合性国际诊断访谈,结构化临床访谈dsm - iv,汉密尔顿抑郁量表,汉密尔顿焦虑量表,Yale-Brown强迫性的规模。结果:NMC参与者没有报告任何精神疾病的历史。 Findings in MMC and NC groups included anxiety (MMC 48, NC 41%), mood (MMC 50%, NC 22%), psychotic (MMC 19%, NC 0%), and substance abuse/dependence (MMC 38%, NC 27%). Conclusions: ATP1A3 mutations cause a wide spectrum of motor and nonmotor features. Psychotic symptoms tended to emerge before or concurrent with motor symptom onset, suggesting that this could be another expression of the ATP1A3 gene mutation. BFMS=Burke-Fahn-Marsden Dystonia Rating Scale; CIDI=Composite International Diagnostic Interview; DSM=Diagnostic and Statistical Manual of Mental Disorders; HAM-A=Hamilton Anxiety Scale; HAM-D=Hamilton Depression Scale; MMC=motor manifesting carrier; NC=noncarrier; NMC=nonmotor manifesting carrier; NOS=not otherwise specified; RPD=rapid-onset dystonia-parkinsonism; UPDRS=Unified Parkinson's Disease Rating Scale; Y-BOCS=Yale-Brown Obsessive-Compulsive Scale ER -