RT期刊文章SR电子T1精神疾病迅速发生dystonia-parkinsonism摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP 1168 OP 1173 1首页0.1212 / WNL。0 b013e3182698d6c VO 79 11 A1 Allison Brashear A1贾里德·f·库克A1黛博拉·f·希尔A1阿勒西娅Amponsah A1贝弗利·m·Snively A1兰妮光A1妮基·博格斯A1辛西娅·k·Suerken A1马克史黛西A1劳丽Ozelius A1凯萨琳j . Sweadner A1 W。沃恩考尔年2012 UL http://n.neurology.or首页g/content/79/11/1168.abstract AB目的:急性dystonia-parkinsonism (RDP)是由各种各样的错义突变ATP1A3基因。精神疾病已经报道,尽管精神疾病的系统检测与RDP缺乏个人。本研究探讨精神病发病率23 RDP患者10家庭与家庭成员对照组和3无关的RDP的患者,共56人。方法:29 ATP1A3 mutation-positive个人检查;26日展出运动症状(电机展现载体(MMC))和3没有(nonmotor展现运营商(NMC))。27 ATP1A3 mutation-negative参与者(非携带者(NC))都包括在内。的心理疾病率RDP和相关的无症状患者的基因突变携带者与相关nonmutation运营商比较。结果评价包括统一帕金森病评定量表,Burke-Fahn-Marsden肌张力障碍评定量表,工具性日常生活活动,复合性国际诊断访谈,结构化临床访谈dsm - iv,汉密尔顿抑郁量表,汉密尔顿焦虑量表,Yale-Brown强迫性的规模。 Results: NMC participants did not report any history of psychiatric disorder. Findings in MMC and NC groups included anxiety (MMC 48, NC 41%), mood (MMC 50%, NC 22%), psychotic (MMC 19%, NC 0%), and substance abuse/dependence (MMC 38%, NC 27%). Conclusions: ATP1A3 mutations cause a wide spectrum of motor and nonmotor features. Psychotic symptoms tended to emerge before or concurrent with motor symptom onset, suggesting that this could be another expression of the ATP1A3 gene mutation. BFMS=Burke-Fahn-Marsden Dystonia Rating Scale; CIDI=Composite International Diagnostic Interview; DSM=Diagnostic and Statistical Manual of Mental Disorders; HAM-A=Hamilton Anxiety Scale; HAM-D=Hamilton Depression Scale; MMC=motor manifesting carrier; NC=noncarrier; NMC=nonmotor manifesting carrier; NOS=not otherwise specified; RPD=rapid-onset dystonia-parkinsonism; UPDRS=Unified Parkinson's Disease Rating Scale; Y-BOCS=Yale-Brown Obsessive-Compulsive Scale