TY - T1的描述与路易体痴呆的扩散张量成像JF -神经学乔-神经病学SP - 906 LP - 914 - 10.1212 / WNL。首页0 b013e318266fc51六世- 79 - 9 AU -罗西沃森盟安德鲁·m·Blamire AU -肖恩·j·Colloby盟Josh美国木材AU -罗伯特·巴伯盟中国他盟——约翰·t·奥布莱恩Y1 - 2012/08/28 UR - //www.ez-admanager.com/content/79/9/906.abstract N2 -目的:探讨体内白质束的模式改变使用扩散张量首页成像(DTI),我们进行了一项横断面研究路易体痴呆的(下文)相比,阿尔茨海默病(AD)和正常老化。方法:研究包括106例(35下文,36与广告,和35老年人控制)接受临床和神经心理评估和扩散张量磁共振成像。我们使用tract-based空间统计调查的模式降低分数各向异性(FA)和增加平均扩散系数(MD)在整个白质束骨架也研究与临床特征的相关性。结果:减少领域FA与下文对控制对象主要被发现在parieto-occipital白质束;在广告中,变化更加分散。下文也与减少FA脑桥和左丘脑与广告相比。医学的模式增加分散在广告和下文。我们发现DTI参数与情景记忆受损,信流畅,在下文电机帕金森症和严重程度。结论:尽管痴呆严重程度相似的水平,DTI广告和下文的变化模式显著不同。 The selective involvement of the visual association areas and subcortical structures and the significant clinical correlations highlight the potential importance of white matter tract change in the pathogenesis of DLB. DTI may be a useful technique to investigate early and possible preclinical changes in DLB and warrants further investigation. AD=Alzheimer disease; BVMT=Brief Visual Memory Task–Revised; CAMCOG=Cambridge Cognitive Examination; DLB=dementia with Lewy bodies; DTI=diffusion tensor imaging; FA=fractional anisotropy; FWE=familywise error; HVLT=Hopkins Verbal Learning Test; ILF=inferior longitudinal fasciculus; MD=mean diffusivity; MMSE=Mini-Mental State Examination; NPI=Neuropsychiatric Inventory; ROI=region of interest; TBSS=tract-based spatial statistics; TFCE=threshold-free cluster enhancement algorithm; UPDRS-III=Unified Parkinson's Disease Rating Scale Part III; VBM=voxel-based morphometry ER -