TY - MRI的T1 -焦萎缩和路易体痴呆与摩根富林明neuropathologic分类——神经学乔-神经病学SP - 553 LP - 560 - 10.1212 / WNL。首页0 b013e31826357a5六世- 79 - 6盟Kejal Kantarci AU -坦尼斯j . Ferman盟布拉德利f . Boeve AU -斯蒂芬·d·Weigand AU -斯科特Przybelski盟Prashanthi Vemuri AU -梅丽莎·m·默里盟马修·l·Senjem AU -格伦·e·史密斯盟David s . Knopman AU -罗纳德·c·彼得森AU -克利福德·r·杰克,Jr . AU -约瑟夫·e·帕里盟丹尼斯·w·迪克森Y1 - 2012/08/07 UR - //www.ez-admanager.com/content/79/6/553.abstract N2 -目的:确定之间的关联措施在临死前的MRI和灶状萎缩后期neuropathologic路易体痴呆与分类(下文)使用下文财团的第三份报首页告标准。方法:我们回顾性56个受试者接受了临死前的MRI和路易体(磅)病理尸检。受试者按病理分类(n = 25),中间(n = 22),和低可能性下文(n = 9)根据下文财团的第三份报告标准。我们包括2额外的病理对照组没有磅:一个阿尔茨海默病(AD)(可能性较低的控制;n = 27)和一个高可能性广告(n = 33)。之间的关联mri体积测量和下文的病理分类进行了协方差分析,通过调整年龄、性别和MRI-to-death区间。Results: Antemortem hippocampal and amygdalar volumes increased from low to intermediate to high likelihood DLB (p < 0.001, trend test). Smaller hippocampal and amygdalar volumes were associated with higher Braak neurofibrillary tangle stage (p < 0.001). Antemortem dorsal mesopontine gray matter (GM) atrophy was found in those with high likelihood DLB compared with normal control subjects (p = 0.004) and those with AD (p = 0.01). Dorsal mesopontine GM volume decreased from low to intermediate to high likelihood DLB (p = 0.01, trend test). Conclusion: Antemortem hippocampal and amygdalar volumes increase and dorsal mesopontine GM volumes decrease in patients with low to high likelihood DLB according to the Third Report of the DLB Consortium criteria. Patients with high likelihood DLB typically have normal hippocampal volumes but have atrophy in the dorsal mesopontine GM nuclei. AD =Alzheimer disease; AUROC =area under the receiver operating characteristic curve; CERAD =Consortium to Establish a Registry for Alzheimer's Disease; DLB =dementia with Lewy bodies; GM =gray matter; LB =Lewy bodies; MCI =mild cognitive impairment; NFT =neurofibrillary tangle; ROI =region of interest. ER -