RT期刊文章SR电子T1焦手肌张力障碍摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金首页斯SP 122 OP 128 10.1212 / WNL。0 b013e31823efce6 VO 78 A1是2 d·怀斯A1 r .根特纳A1 d .西A1。内格尔A1 c Reinsberger A1 j j。Rumpf A1 j·克拉森年2012 UL http://n.neurolog首页y.org/content/78/2/122.abstract AB目的:研究皮质脊髓的系统是否来自组织的初级运动皮层可能促进代矛盾的运动。方法:在这个横断面观察研究,手指运动(FM)表示在10焦手肌张力障碍患者进行评估(FHD)和10个匹配的健康对照组经颅磁刺激在休息。右手的手指运动激活的记录使用测试数据手套。手指关节运动模式使用聚类分析进行了分析。主成分分析和重力中心的手指运动表象和运动诱发电位记录外展全身和外展digiti最小的肌肉被计算。相比之下,高分辨率的躯体感觉诱发电位(SSEP)记录后电刺激的拇指(D1)或小指(D5)在同一病人。源重建N20 SSEP组件使用dual-dipole执行模型。结果:刺激的运动皮层休息没有透露FHD明显异常,对手指关节运动模式和对拓扑结构的组织手指运动或手内在肌表示。 However, in line with previous reports, the distance between the dipole sources of D1 and D5 in the somatosensory cortex (S1) was smaller in patients with FHD, suggesting disruption of homuncular finger representations in S1. Conclusions: Our findings may imply that abnormality of motor organization in focal hand dystonia arises principally only during activation, when abnormal somatosensory representations are functionally integrated. ADM=abductor digiti minimi; ANOVA=analysis of variance; APB=abductor pollicis brevis; CoG=center of gravity; FHD=focal hand dystonia; FM=finger movement; M1=primary motor cortex; MEP=motor evoked potential; PC=principal component; PV=posture vector; S1=somatosensory cortex; SSEP=somatosensory evoked potential; TMS=transcranial magnetic stimulation