作者@article {Weise122 = {D。根特纳怀斯和r . a和d·西格尔和c Reinsberger和j j。Rumpf和j·克拉森}、标题={焦手肌张力障碍},体积={78}={2},页面= {122 - 128}= {2012},doi = {10.1212 / WNL。出版商0 b013e31823efce6} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:检查是否源自初级运动皮质皮质脊髓的系统可能会组织促进代矛盾的运动。首页方法:在这个横断面观察研究,手指运动(FM)表示在10焦手肌张力障碍患者进行评估(FHD)和10个匹配的健康对照组经颅磁刺激在休息。右手的手指运动激活的记录使用测试数据手套。手指关节运动模式使用聚类分析进行了分析。主成分分析和重力中心的手指运动表象和运动诱发电位记录外展全身和外展digiti最小的肌肉被计算。相比之下,高分辨率的躯体感觉诱发电位(SSEP)记录后电刺激的拇指(D1)或小指(D5)在同一病人。源重建N20 SSEP组件使用dual-dipole执行模型。 Results: Stimulation of the resting motor cortex did not reveal overt abnormalities in FHD, neither with respect to finger joint movement patterns nor with respect to the topologic organization of finger movements or intrinsic hand muscle representations. However, in line with previous reports, the distance between the dipole sources of D1 and D5 in the somatosensory cortex (S1) was smaller in patients with FHD, suggesting disruption of homuncular finger representations in S1. Conclusions: Our findings may imply that abnormality of motor organization in focal hand dystonia arises principally only during activation, when abnormal somatosensory representations are functionally integrated. ADM=abductor digiti minimi; ANOVA=analysis of variance; APB=abductor pollicis brevis; CoG=center of gravity; FHD=focal hand dystonia; FM=finger movement; M1=primary motor cortex; MEP=motor evoked potential; PC=principal component; PV=posture vector; S1=somatosensory cortex; SSEP=somatosensory evoked potential; TMS=transcranial magnetic stimulation}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/78/2/122}, eprint = {//www.ez-admanager.com/content/78/2/122.full.pdf}, journal = {Neurology} }