TY -的T1 -特异性神经元烯醇酶与其他预后标记后心脏骤停JF -神经学乔-神经病学SP - 623 LP - 630 - 10.1212 / WNL。首页0 b013e31822a276d六世- 77 - 7 AU - t . Cronberg AU - m . Rundgren AU - e . Westhall AU - e·英格伦盟- r . Siemund AU -罗森盟——h·威德纳盟——h·弗里Y1 - 2011/08/16 UR - //www.ez-admanager.com/content/77/7/623.a首页bstract N2 -目的:低温治疗(TH)是一个推荐的治疗心脏骤停的幸存者。预测是复杂自镇静和放松肌肉,并建立预后不良的指标缺乏。这种前瞻性,观察研究描述了常用的预后标志物的模式在hypothermia-treated群心脏骤停患者长时间的昏迷。方法:111个连续的患者中,1188金宝慱官网下载9岁死了,58恢复,和34在昏迷3天正常体温后心脏骤停后(4.5天),定义为长期昏迷。所有患者监测连续amplitude-integrated脑电图和重复样品特异性神经元烯醇酶(了无)收集。长时间的昏迷,患者躯体感觉诱发电位(SSEP)和脑MRI进行。后期的大脑进行调查的患者死亡。结果:17个患者(35%)的六个了无水平& lt; 33μg / L在48小时内恢复能力服从口头命令。相比之下,17个病人了无水平在33未能恢复意识。 In the >33 NSE group, all 10 studied with MRI had extensive brain injury on diffusion-weighted images, 12/16 lacked cortical responses on SSEP, and all 6 who underwent autopsy had extensive severe histologic damage. NSE levels also correlated with EEG pattern, but less uniformly, since 11/17 with NSE <33 had an electrographic status epilepticus (ESE), only one of whom recovered. A continuous EEG pattern correlated to NSE <33 and awakening. Conclusions: NSE correlates well with other markers of ischemic brain injury. In patients with no other signs of brain injury, postanoxic ESE may explain a poor outcome. aEEG=amplitude-integrated EEG monitoring; CA=cardiac arrest; CPC=Cerebral Performance Categories Scale; DWI=diffusion-weighted image; ESE=electrographic status epilepticus; GCS-M=motor response to pain according to Glasgow Coma Scale; ICU=intensive care unit; IQR=interquartile range; NSE=neuron-specific enolase; ROC=receiver operating characteristic; SB=suppression burst; SSEP=somatosensory evoked potential; TH=therapeutic hypothermia ER -