PT -期刊文章盟g . Disanto AU - s Magalhaes盟A.E.韩德尔盟K.M.莫里森AU -公元Sadovnick盟G.C.埃伯斯盟a - b . Banwell盟酒吧或者TI - HLA-DRB1带来的风险增加pediatric-onset女士的孩子获得髓鞘脱失援助- 10.1212 / WNL。0 b013e31820ee1cd DP - 2011年3月01 TA -神经首页病学第六PG - 781 - 786 - 76 IP - 9 4099 - //www.ez-admanager.com/content/76/9/781.short 4100 - //www.ez-admanager.com/content/76/9/781.full所以Neurology2011 3月01;76 AB -背景:多发性硬化症(MS)在儿童年龄组被越来越多的认可。在成人中,遗传和环境因素之间复杂的相互作用导致风险和女士的主要遗传因素敏感性定位的主要组织相容性复合体(人类白细胞抗原(HLA))。女士是否HLA等位基因预测高危儿童呈现与获得性脱髓鞘综合症(广告)的中枢神经系统是未知的。方法:输入使用allele-specific HLA-DRB1等位基因PCR扩增方法样本266名儿童提供与广告进入未来的加拿大儿科脱髓鞘疾病研究和从196年健康对照组。结果:六十四年的266名儿童广告满足了标准诊断的女士在一个平均3.2±1.5年的随访。孩子窝藏DRB1 * 15等位基因更有可能被诊断为女士(χ2 = 12.2,p & lt;0.001;或= 2.7),观察了欧洲血统的孩子(χ2 = 10.5,p = 0.001;或= 3.3)。 DRB1*15 allele frequencies in children with ADS of European ancestry subsequently diagnosed with MS were greater than in children with monophasic ADS (χ2 = 10.7, p = 0.001) or healthy controls (χ2 = 12.5, p < 0.001). The proportion of children with non-European ancestry diagnosed with MS was not influenced by DRB1*15 status. Conclusion: DRB1*15 alleles confer increased susceptibility to pediatric-onset MS, supporting a fundamental similarity in genetic contribution to MS risk in both pediatric- and adult-onset disease. The specificity of the DRB1*15 risk allele for children with subsequent MS diagnosis, but not for all children with ADS, indicates that the risk conveyed by DRB1*15 relates to chronic CNS disease (MS), rather than acquired demyelination in general.

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