作者@article {Criswell1296 ={狭义相对论克里斯和J.S.二波尔马特和世贸组织Videen克里莫尔林恩和惠普弗洛雷斯和点Birke文学士学位Racette}, title ={减少吸收[18 f] FDOPA宠物在无症状的焊工职业性锰暴露},体积={76}={15},页面= {1296 - 1301}= {2011},doi = {10.1212 / WNL。出版商0 b013e3182152830} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:焊接暴露工人锰(Mn)烟雾,但目前还不清楚如果暴露在基底神经节损害多首页巴胺神经元,容易使人患帕金森症。PET成像与6 - [18 f] fluoro-l-dopa (FDOPA)是一种非侵入式测量黑的多巴胺能神经元完整性。本研究的目的是确定是否焊接接触与黑损伤神经元在无症状的工人。方法:我们拍摄20无症状的焊工接触锰烟雾、20科目与特发性帕金森病(IPD)和20名正常对照组使用FDOPA宠物。所有受试者运动障碍专家检查。基底神经节的兴趣被确定为每个主题。的特定吸收FDOPA Ki,为每个地区使用生成的图形分析方法。结果:重复措施一般线性模型(GLM)分析了诊断集团和地区之间的强相互作用(F4,112 = 15.36, p < 0.001)。 Caudate Kis were lower in asymptomatic welders (0.0098 + 0.0013 minutes-1) compared to control subjects (0.0111 + 0.0012 minutes-1, p = 0.002). The regional pattern of uptake in welders was most affected in the caudate \> anterior putamen \> posterior putamen. This uptake pattern was anatomically reversed from the pattern found in subjects with IPD. Conclusions: Active, asymptomatic welders with Mn exposure demonstrate reduced FDOPA PET uptake indicating dysfunction in the nigrostriatal dopamine system. The caudate Ki reduction in welders may represent an early (asymptomatic) marker of Mn neurotoxicity and appears to be distinct from the pattern of dysfunction found in symptomatic IPD.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/76/15/1296}, eprint = {//www.ez-admanager.com/content/76/15/1296.full.pdf}, journal = {Neurology} }