TY - T1的大脑异常代谢网络在图雷特综合症JF -神经学乔-神经病学SP - 944 LP - 952 - 10.1212 / WNL。首页0 b013e3182104106六世- 76 - 11盟费金a - m . Pourfar盟盟林祖嘉唐盟- m . Carbon-Correll盟m . Bussa AU - c . Budman盟Dhawan诉AU - d Eidelberg Y1 - 2011/03/15 UR - //www.ez-admanager.com/content/76/11/944.abstract首页 N2 -目的:识别大脑代谢网络与抽动秽语综合征(TS)和共病强迫症(OCD)。方法:我们利用[18 f]氟脱氧葡萄糖PET成像检查大脑新陈代谢在12个犯人TS患者和12个年龄组。我们利用一个空间协方差分析来识别2大脑疾病代谢网络,一个与TS(区分TS对象和控制),和另一个关联强迫症严重程度(仅对TS组内)。Results: Analysis of the combined group of patients with TS and healthy subjects revealed an abnormal spatial covariance pattern that completely separated patients from controls (p < 0.0001). This TS-related pattern (TSRP) was characterized by reduced resting metabolic activity of the striatum and orbitofrontal cortex associated with relative increases in premotor cortex and cerebellum. Analysis of the TS cohort alone revealed the presence of a second metabolic pattern that correlated with OCD in these patients. This OCD-related pattern (OCDRP) was characterized by reduced activity of the anterior cingulate and dorsolateral prefrontal cortical regions associated with relative increases in primary motor cortex and precuneus. Subject expression of OCDRP correlated with the severity of this symptom (r = 0.79, p < 0.005). Conclusion: These findings suggest that the different clinical manifestations of TS are associated with the expression of 2 distinct abnormal metabolic brain networks. These, and potentially other disease-related spatial covariance patterns, may prove useful as biomarkers for assessing responses to new therapies for TS and related comorbidities. ER -