TY -的T1 -使用布洛芬和帕金森疾病的风险JF -神经学乔-神经病学SP - 863 LP - 869 - 10.1212 / W首页NL。0 b013e31820f2d79六世- 76 - 10 AU -香高盟宏磊陈盟-迈克尔·a·史瓦西盟Alberto Ascherio博士Y1 - 2011/03/08 UR - //www.ez-admanager.com/content/76/10/863.abstract N2 -背景:神首页经炎症可能导致帕金森病(PD)的发病机理。使用非甾体类抗炎药(非甾体抗炎药)一般来说,尤其是可能是布洛芬,已被证明是相关的风险降低PD在以前的流行病学研究。方法:前瞻性研究是否使用布洛芬和其它非甾体抗炎药风险降低PD护士健康研究的136197名参与者(NHS)和卫生专业人员随访研究(HPFS分区)免费的PD基线HPFS分区为NHS(1998和2000)。非甾体抗炎药的使用是通过问卷调查评估。结果合并在一个荟萃分析与发布前瞻性调查。结果:我们发现291 PD发病病例在6年的随访。布洛芬的用户比使用者风险显著降低PD(相对危险度(RR),调整年龄,吸烟,咖啡因,和其他协变量= 0.62;95%可信区间[CI] 0.42 - -0.93;p = 0.02)。 There was a dose–response relationship between tablets of ibuprofen taken per week and PD risk (p trend = 0.01). In contrast, PD risk was not significantly related to use of aspirin (RR = 0.99; 95% CI 0.78–1.26), other NSAIDs (RR = 1.26; 95% CI 0.86–1.84), or acetaminophen (RR = 0.86; 95% CI 0.62–1.18). Similar results were obtained in the meta-analyses: the pooled RR was 0.73 (95% CI 0.63–0.85; p < 0.0001) for ibuprofen use, whereas use of other types of analgesics was not associated with lower PD risk. Conclusions: The association between use of ibuprofen and lower PD risks, not shared by other NSAIDs or acetaminophen, suggests ibuprofen should be further investigated as a potential neuroprotective agent against PD. ER -