TY -的T1 -正改善手术结果负MRI的泰勒式焦皮质发育不良JF -神经学乔-神经病学SP - 2168 LP - 2175 - 10.1212 / WNL。首页0 b013e31820203a9六世- 75 - 24盟- f . Chassoux AU - s罗德里戈AU - f . Semah AU - f . Beuvon AU - e . Landre AU - b . Devaux AU - b . Turak AU - c Mellerio AU -肯尼迪。地中海联盟——F.-X。Roux AU - c . Daumas-Duport AU - p . Merlet AU - o .霍华斯盟- c凯龙星Y1 - 2010/12/14 UR - http://n.neurology首页.org/content/75/24/2168.abstract N2 -目的:确定的诊断准确性和预后价值18正子在最近的一系列病理组织切片证实运营了棘手的部分癫痫与泰勒式焦皮质发育不良(TTFCD)和消极的核磁共振。方法:连续23例(12男,7-38岁)为负1.5特斯拉MRI, 10表现出微妙的非特异性异常(例如,不同寻常的沟深度或旋转的模式)和13人严格正常MRI。正分析视觉coregistration后MRI和使用SPM5软件。代谢数据与病灶(EZ)由stereo-EEG (SEEG)和手术结果。结果:视觉宠物分析披露焦或区域代谢减退在18例(78%)对应于一个回(n = 9)或一个更大的大脑皮层区域(n = 9)。PET / MRI coregistration发现部分觉回另外4例。SPM5宠物分析(n = 18)与视觉整合分析13例。宠物的位置异常是extratemporal在所有情况下,涉及雄辩的皮层在15 (65%)。SEEG之间的相关性,PET / MRI和组织学结果(n = 20)表明,单一觉脑回(n = 11)与EZ TTFCD,局部底部的沟。 Larger hypometabolic areas (n = 9) also included the EZ and the dysplastic cortex but were more extensive. Following limited cortical resection (mean follow-up 4 years), seizure freedom without permanent motor deficit was obtained in 20/23 patients (87%). Conclusions: 18FDG-PET coregistered with MRI is highly sensitive to detect TTFCD and greatly improves diagnosis and surgical prognosis of patients with negative MRI. ER -