PT -期刊文章AU - f . Chassoux AU - s罗德里戈盟- f . Semah盟- f . Beuvon AU - e . Landre盟- b . Devaux AU - b Turak AU - c . Mellerio AU -肯尼迪。地中海联盟——F.-X。Roux AU - c . Daumas-Duport AU - p . Merlet AU - o .霍华斯盟- c凯龙星TI -正改善手术结果负MRI的泰勒式焦皮质发育不良- 10.1212 / WNL的援助。0 b013e31820203a9 DP - 2010年12月14日TA -神首页经病学第六PG - 2168 - 2175 - 75 IP - 24 4099 - //www.ez-admanager.com/content/75/24/2168.short 4100 - //www.ez-admanager.com/content/75/24/2168.full所以Neurology2010 12月14日;75 AB -目的:确定的诊断准确性和预后价值18正子在最近的一系列病理组织切片证实运营了棘手的部分癫痫与泰勒式焦皮质发育不良(TTFCD)和消极的核磁共振。方法:连续23例(12男,7-38岁)为负1.5特斯拉MRI, 10表现出微妙的非特异性异常(例如,不同寻常的沟深度或旋转的模式)和13人严格正常MRI。正分析视觉coregistration后MRI和使用SPM5软件。代谢数据与病灶(EZ)由stereo-EEG (SEEG)和手术结果。结果:视觉宠物分析披露焦或区域代谢减退在18例(78%)对应于一个回(n = 9)或一个更大的大脑皮层区域(n = 9)。PET / MRI coregistration发现部分觉回另外4例。SPM5宠物分析(n = 18)与视觉整合分析13例。 Location of PET abnormalities was extratemporal in all cases, involving eloquent cortex in 15 (65%). Correlations between SEEG, PET/MRI, and histologic findings (n = 20) demonstrated that single hypometabolic gyri (n = 11) corresponded to EZ and TTFCD, which was localized at the bottom of the sulcus. Larger hypometabolic areas (n = 9) also included the EZ and the dysplastic cortex but were more extensive. Following limited cortical resection (mean follow-up 4 years), seizure freedom without permanent motor deficit was obtained in 20/23 patients (87%). Conclusions: 18FDG-PET coregistered with MRI is highly sensitive to detect TTFCD and greatly improves diagnosis and surgical prognosis of patients with negative MRI.

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