TY - T1的白质变化和糖尿病预测老年人认知衰退JF -神经学乔-神经病学SP - 160 LP - 167 - 10.1212 / WNL。首页0 b013e3181e7ca05六世- 75 - 2非盟- a . Verdelho盟美国Madureira AU - c . Moleiro盟J.M.铁盟狱警桑托斯AU - t . Erkinjuntti AU - l . Pantoni AU - f·法泽卡斯盟——m·维瑟盟——g·沃尔德盟——a·沃林AU - m . Hennerici AU - d . Inzitari A2, Y1 - 2010/07/13 UR - //www.ez-admanager.com/content/75/2/160.abstract N2 -目的:我们旨在研究如果年龄相关性白首页质改变(WMC)和血管危险因素预测老年人认知衰退的WMC独立生活。方法:Leukoaraiosis和残疾前瞻性跨国欧洲研究(LADIS)评估的影响WMC独立老年人残疾的过渡。独立的老人为由于WMC的存在。受试者的3年期间,每年评估一个全面的临床协议和神经心理学电池。此外,老年痴呆症,痴呆的亚型,认知能力下降无痴呆的分类根据平时临床标准。MRI表现在进入最后的研究。结果:共有639名受试者包括(74.1±5年,55%的女性,9.6±3.8年的学校教育)。最后的随访中,90名患者没有147痴呆和认知障碍痴呆。使用Cox回归分析,WMC严重性独立预测认知能力下降(痴呆和非痴呆),独立于年龄、教育、和内侧颞萎缩(MTA)。 Diabetes at baseline was the only vascular risk factor that independently predicted cognitive decline during follow-up, controlling for age, education, WMC severity, and temporal atrophy. Considering subtypes of dementia, Alzheimer disease (AD) was predicted only by MTA, while vascular dementia was predicted by previous stroke, WMC severity, and MTA. Conclusion: WMC severity and diabetes are independent predictors of cognitive decline in an initially nondisabled elderly population. Vascular dementia is predicted by previous stroke and WMC, while AD is predicted only by MTA. ER -