TY -的T1序列磁共振成像和脑脊液生物标记物在正常老化,MCI和广告摩根富林明——神经学乔-神经病学SP - 143 LP - 151 - 10.1212 首页/ WNL。0 b013e3181e7ca82六世- 75 - 2非盟- p . Vemuri盟H.J. Wiste AU - s.d Weigand盟科学博士Knopman AU - J.Q. Trojanowski AU -肖L.M.盟硕士伯恩斯坦AU -注:爱森盟- m·维纳盟- R。C彼得森AU - C。R杰克,Jr . A2 - Y1 - 2010/07/13 UR - http://n.neuro首页logy.org/content/75/2/143.abstract N2 -目的:比较MRI的年度变化和脑脊液生物标志物在认知正常(CN)、遗忘轻度认知障碍(aMCI)和阿尔茨海默病(AD)。比较是基于群际歧视,相关性与并发认知/功能变化,APOE基因型之间的关系,为临床试验样本量。方法:我们使用的数据的阿尔茨海默病的神经影像学研究包括CN, aMCI,广告组基线和12个月的随访CSF和MRI。CSF的年度变化(total-tau t-tau, Aβ1-42)和核磁共振(心室体积变化)于312年获得受试者(92 CN, 149 aMCI,公元71年)。结果:没有明显的年平均变化脑脊液生物标志物在临床组除了CN t-tau;此外,年度变化没有差别,临床组两两比较。相比之下,每年按照以下顺序增加心室体积增加,广告比;aMCI祝辞 CN, and differences were significant between all clinical groups in pairwise comparisons. Ventricular volume increase correlated with concurrent worsening on cognitive/functional indices in aMCI and AD whereas evidence of a similar correlation with change in CSF measures was unclear. The annual changes in MRI differed by APOE ε4 status overall and among aMCI while annual changes in CSF biomarkers did not. Estimated sample sizes for clinical trials are notably less for MRI than the CSF or clinical measures. Conclusions: Unlike the CSF biomarkers evaluated, changes in serial structural MRI are correlated with concurrent change on general cognitive and functional indices in impaired subjects, track with clinical disease stage, and are influenced by APOE genotype. ER -