RT期刊文章SR电子T1眼球运动障碍是不同的帕金联系和特发性早发性帕金森病摩根富林明神经病学神经学乔FD Lippincott W首页illiams &威尔金斯SP 125 OP 128 10.1212 / WNL。0 b013e3181e7ca6d VO 75是2 A1 b Machner A1 c·克莱因A1。斯派格A1 p·鲍姆巴赫的A1 P.P. Pramstaller A1 c Helmchen A1 W。海德年2010 UL http://n.neurol首页ogy.org/content/75/2/125.abstract AB目的:帕金基因突变是早发性帕金森症的最常见原因。帕金突变可能是临床患者的特发性患者早发性帕金森病(EOPD)没有帕金突变。眼球运动障碍已被证明微分帕金森综合症,但从来没有系统地研究了帕金突变携带者。方法:记录眼球运动(n = 9)症状和无症状的帕金突变携带者(n = 13)、特发性患者EOPD (n = 14),和年龄对照组(n = 27)在建立动眼神经的任务。结果:患者EOPD和帕金突变携带者症状显示hypometric prosaccades向视觉刺激,以及赤字抑制反身跳阅向意想不到的目标(任务)的人群。当导演的目光朝着记忆目标位置,患者EOPD展出hypometric跳阅、而帕金突变携带者症状显示正常跳阅。EOPD患者相比,帕金突变携带者症状显示受损的跟踪移动目标(减少光滑的追求获得)。无症状的帕金突变携带者没有不同于健康对照组的任务。 Conclusions: Although clinically similarly affected, symptomatic Parkin mutation carriers and patients with idiopathic EOPD differed in several oculomotor tasks. This finding may point to distinct anatomic structures underlying either condition: dysfunctions of cortical areas involved in smooth pursuit (V5, frontal eye field) in Parkin-linked parkinsonism vs greater impairment of basal ganglia circuits in idiopathic Parkinson disease.