TY - T1的脑干病变临床孤立综合征JF -神经学乔-神经病学SP - 1933 LP - 1938 - 10.1212 / WNL。首页0 b013e3181feb26f六世- 75 - 21 AU - m . Tintore AU - a·罗维拉盟- g . Arrambide AU - r . Mitjana AU - j .力拓盟- c .钻盟- c Nos AU -贝拉江户AU - j·卡斯蒂略AU - a Horga AU - f . Perez-Miralles盟大肠Huerga AU - m . Comabella AU - j . Sastre-Garriga AU - x好吃Y1 - 2010/11/23 UR - //www.ez-admanager.com/content/75/21/1933.abstract N2 -首页背景:基线的病变可以预测未来的攻击和残疾临床孤立综合征(CIS)。摘要目的:探讨基线infratentorial病变长期预后的作用。方法:受试者包括CIS患者的前瞻性群组。病人接受了脑部MRI CIS发病后3个月内。数量和位置的病变在基线前瞻性研究。回顾进行扫描分析具体看看infratentorial病变的数量和位置。我们分析了第二次攻击,达到eds 3.0。结果:我们与CIS包括246例平均随访7.7年。infratentorial病变患者都转换的风险更高(71.4% vs 29.6%; hazard ratio [HR] 3.3; 95% confidence interval [CI] 2.2–4.8; p < 0.001) and of developing disability (32.5% vs 12.4%; HR 2.4; 95% CI 1.3–4.3; p = 0.003). Presence of at least one cerebellar lesion was associated with an increased risk of conversion (HR 2.4; 95% CI 1.3–4.5; p = 0.007). Presence of at least one brainstem lesion increased both the risk of conversion (HR 2.9; 95% CI 1.7–5.0; p < 0.001) and disability (HR 2.5; 95% CI 1.1–5.4; p = 0.026). Broken down into number of lesions, the presence of infratentorial lesions increased both the risk of conversion (83% vs 61%) (HR 22.3; 95% CI 9.7–51.1; p < 0.001) and of reaching EDSS 3.0 (40% vs 19%) (HR 3.2; 95% CI 1.3–7.4; p = 0.008) only in patients with 9 or more lesions. Conclusions: Presence of infratentorial lesions increases the risk for disability. Brainstem rather than cerebellar lesions may be responsible for poor prognosis. ER -