TY -的T1 -使用抗癫痫药物在癫痫和自残或自杀行为的风险,摩根富林明-神经学乔-神经病学SP - 335 LP - 340 - 10.1212 / WNL。首页0 b013e3181ea157e六世- 75 - 4 AU -弗兰克Andersohn盟盟雷内·谢德-斯蒂芬·n·Willich盟Edeltraut Garbe Y1 - 2010/07/27 UR - //www.ez-admanager.com/content/75/4/335.a首页bstract N2 -背景:最近的一项荟萃分析的随机试验表明,抗癫痫药物(aed)为类增加自杀想法和行为的风险。我们进行了一项观察性研究与数据来自英国全科研究数据库调查如果风险的增加不同组的aed同样明显的是在临床实践中。方法:这是一个嵌套病例对照研究44300年一群癫痫患者服用aed。自残或自杀行为患者被预定义的标识码。我们包含了453起病例和8962年龄和sex-matched控制。aed被分为4组:较低的巴比妥酸盐,传统aed,新的aed(拉莫三嗪、加巴喷丁、普加巴林,奥卡西平)或高(levetiracetam tiagabine,托吡酯,氨己烯酸)可能导致抑郁症。调整后的优势比(或)使用条件逻辑回归计算。结果:当前使用和高潜力的新aed。导致抑郁与三倍自残或自杀行为的风险增加(OR = 3.08;95% (CI) 1.22 -7.77),相比之下,在去年没有使用aed。 Use of barbiturates (OR = 0.66; 95% CI 0.25–1.73), conventional AEDs (OR = 0.74; 95% CI 0.53–1.03), or low-risk newer AEDs (OR = 0.87; 95% CI 0.47–1.59) was not associated with an increased risk. Conclusions: Newer AEDs with a rather high frequency of depressive symptoms in clinical trials may also increase the risk of self-harm or suicidal behavior in clinical practice. For the most commonly used other groups of AEDs, no increase in risk was observed. ER -