TY - T1的抗癫痫药物反应在颞叶癫痫JF -神经学乔-神经病学SP - 1695 LP - 1701 - 10.1212 / WNL。首页0 b013e3181fc29dd六世- 75 - 19 AU - e Bilevicius盟盟中一段Yasuda -硕士席尔瓦盟C.A.M. Guerreiro AU - i Lopes-Cendes盟f . Cendes Y1 - 2010/11/09 UR - //www.ez-admanager.com/content/75/19/16首页95.abstract N2 -目的:探讨脑MRI和临床特征之间的关系和模式的抗癫痫药物(AED)响应中央的颞叶癫痫患者(MTLE)。方法:总共有165 MTLE患者分为控制发作AED (AED反应者,n = 50), pharmacoresistant (n = 87)、和remitting-relapsing发作对照组(n = 28)。所有组进行评估有关年龄、发作频率,和年龄在癫痫发作,癫痫,期间发热性癫痫,存在和海马萎缩(HA),和初始诱发损伤。灰质(GM) MRI分布形态测量学(VBM)我们选择只有单边患者HA视觉核磁共振分析(n = 100)。比较了所有组之间和75名健康对照组。结果:癫痫发病年龄较低(p = 0.005)和首次癫痫发作的频率更高的pharmacoresistant较其他两组(p = 0.018)。所有组显示通用汽车在侧海马萎缩控制相比,双边海马旁回、额叶、枕叶、顶叶和小脑等领域。AED反应组,这样的调查结果更局限于区域侧pharmacoresistant癫痫病灶,范围更加广泛,remitting-relapsing组。VBM pairwise comparisons showed areas with GM volume reduction in the pharmacoresistant and remitting-relapsing groups compared with AED responders in bilateral periorbital frontal (p < 0.01), cingulum (p < 0.05), and temporal lobe contralateral to the epileptic focus (p < 0.05). Conclusions: Pharmacoresistant and remitting-relapsing groups presented a similar pattern of GM atrophy, which was more widespread compared with AED responders. Conversely, age at epilepsy onset was lower and initial seizure frequency was higher in pharmacoresistant patients. ER -