TY -的T1 -胃粘膜神经密度JF -神经学乔-神经病学SP - 973 LP - 981 - 1首页0.1212 / WNL。0 b013e3181f25f19六世- 75 - 11盟M.M.斯莱姆AU - g . Wendelschafer-Crabb盟J.B. Redmon AU - a . Khoruts盟j.s霍奇斯盟- k .科赫AU - d走盟得到肯尼迪Y1 - 2010/09/14 UR - //www.ez-admanager.com/content/75/11/973.abstract N2 -背景:自主首页神经病变是一个经常引起体位性低血压诊断为胃肠道症状或经历了长期的糖尿病患者。然而,neuropathologic证据来证明诊断是有限的。我们假设量化胃粘膜的神经会确认自主神经病变的存在。方法:从胃腔粘膜活检,眼底得到在内镜从15名健康对照组和13 1型糖尿病胰腺移植候选人曾二次糖尿病并发症影响眼睛,肾脏和神经,包括胃轻瘫的诊断。神经系统状态评估的神经系统检查,神经传导研究,和皮肤活检。胃粘膜活检处理量化神经和表皮神经。Results: Gastric mucosal nerves from diabetic subjects had reduced density and abnormal morphology compared to control subjects (p < 0.05). The horizontal and vertical meshwork pattern of nerve fibers that normally extends from the base of gastric glands to the basal lamina underlying the epithelial surface was deficient in diabetic subjects. Eleven of the 13 diabetic patients had residual food in the stomach after overnight fasting. Neurologic abnormalities on clinical examination were found in 12 of 13 diabetic subjects and nerve conduction studies were abnormal in all patients. The epidermal nerve fiber density was deficient in skin biopsies from diabetic subjects. Conclusions: In this observational study, gastric mucosal nerves were abnormal in patients with type 1 diabetes with secondary complications and clinical evidence of gastroparesis. Gastric mucosal biopsy is a safe, practical method for histologic diagnosis of gastric autonomic neuropathy. ER -