TY -的T1 -主动脉僵硬和脉搏波反射与偏头痛摩根富林明年轻学科——神经学乔-神经病学SP - 960 LP - 966 - 10.1212 / WNL。首页0 b013e3181f25ecd六世- 75 - 11 AU - g . Schillaci AU - p . Sarchielli AU - i Corbelli AU - g .璞琪AU - l . Settimi AU -核磁共振Mannarino AU - p·卡拉布雷西盟大肠Mannarino Y1 - 2010/09/14 UR - //www.ez-admanager.com/conte首页nt/75/11/960.abstract N2 -背景:偏头痛与风险增加有关缺血性中风和其他心血管事件(CV),包括心绞痛、心肌梗死和简历死亡,但偏头痛与CV疾病的机制仍然不确定。我们假设主动脉脉搏波速度(采集)的直接测量主动脉僵硬和中风和心血管疾病的独立预测指标,可能会增加年轻偏头痛患者没有明显的心血管疾病或主要简历风险因素。偏头痛患者方法:我们研究了60±8年33岁时,85%的女性,血压119/74±11/9毫米汞柱),60岁,性,和血液pressure-matched健康对照组。在所有参与者,carotid-femoral采集和主动脉增加指数是由扁平张力测定法。病例和对照组无明显的心血管疾病,糖尿病,和主要心血管危险因素。结果:主题与偏头痛有较高主动脉采集(7.6±1.2 vs 6.4±1.1 m×s−1, p & lt;0.001)和主动脉扩张(心脏调整增强指数,0.17±0.13 vs 0.08±0.15, p & lt;0.001)比匹配的对照组。偏头痛先兆的患者(n = 17)主动脉采集高于那些没有光环(n = 43; 8.2 ± 1.2 vs 7.4 ± 1.1 m×s−1, p = 0.027). Age, mean arterial pressure as a measure of distending pressure, and migraine (all p < 0.05) independently predicted aortic PWV when a consistent number of CV risk factors was simultaneously controlled for. Conclusions: Migraine is independently associated with increased aortic stiffness and enhanced pressure wave reflection. This finding, obtained in young subjects without major CV risk factors, may represent one possible mechanism underlying the increased CV risk in migraine patients. ER -