TY - T1的扩张脑膜中动脉和逆转的CGRP怎样舒马曲坦在正常志愿者JF -神经学乔-神经病学SP - 1520 LP - 1526 - 10.1212 / WNL。首页0 b013e3181f9626a六世- 75 - 17 AU -硕士Asghar盟A.E.汉森AU - t . Kapijimpanga盟R.J. van der地表古积非盟- p . van der通力盟H.B.W.拉尔森AU - j·奥尔森盟m . Ashina Y1 - 2010/10/26 UR - //www.ez-admanager.com/content/75/17/1520.abstract N2 -背景:降首页钙素相关基因肽(CGRP怎样)在神经与血管的头痛的病理生理学中起着基础性作用。CGRP怎样输液会导致头痛和颅内血管的扩张。然而,尚不清楚到什么程度CGRP-induced血管舒张导致立即头痛和migraine-specific是否流产药物舒马曲坦,5 -羟色胺1 b / 1 d受体激动剂,抑制CGRP-induced直接血管舒张和头痛。方法:我们进行了双盲,随机,安慰剂对照,交叉研究的18名健康的志愿者。我们记录的周长变化的脑膜中动脉(MMA)和大脑中动脉(MCA)注入之前和之后使用磁共振血管造影术(20分钟)1.5μg人类αCGRP /分钟或安慰剂(等渗盐水)以及6 mg后舒马曲坦皮下注射。结果:与安慰剂相比,CGRP怎样引起显著扩张MMA (p = 0.006),没有扩张MCA (p = 0.69)。舒马曲坦造成明显收缩MMA(15% - -25.2%)和边际收缩MCA(3.9%到5.3%)。舒马曲坦探险的分析显示,有更多的选择性行动MMA与MCA CGRP怎样天相比(p & lt;0.0001)和安慰剂组(p = 0.007)。 Conclusion: These data suggest that exogenous CGRP dilates extracranial vessels and not intracranial, and that sumatriptan exerts part of its antinociceptive action by constricting MMA and not MCA. Classification of evidence: This study provides Class I evidence that IV GCRP causes dilation of the MMA but not the MCA in healthy volunteers, and that sumatriptan reverses the dilation of the MMA caused by CGRP. ER -