TY - T1的维生素E对顺铂神经病变摩根富林明神经保护——神经学乔-神经病学SP - 762 LP - 766 - 10.1212 / WN首页L。0 b013e3181d5279e六世- 74 - 9 AU - a速度非盟- d . Giannarelli AU - e . Galie盟- a Savarese AU - s Carpano盟- m·德拉会盟- a波齐盟- a . Silvani盟- p . Gaviani盟诉Scaioli AU - b . Jandolo AU - l . Bove盟- f . Cognetti Y1 - 2010/03/02 UR - //www.ez-admanager.com/content/74/9/762.abstract N2 -目首页的:顺铂化疗的临床应用受到严重的周围神经毒性报道多达90%的病人接受累积剂量高于300毫克/平方米。本研究评估神经保护作用的抗氧化补充(维生素E)与顺铂化疗患者。方法:共有108名患者接受顺铂化疗被随机分配接受补充维生素E(α-tocopherol 400 mg /天)和安慰剂。治疗开始前口服化疗和持续了3个月后暂停顺铂。结果:108名随机化患者,68收到至少一个顺铂CT后临床和神经生理学检查;41名患者接受顺铂的累积剂量高于300 mg / m2,符合统计分析:17维生素E组(组1),24日在安慰剂组(组2)。神经毒性的发生率显著低于1组(5.9%)相比,2组(41.7%)(p & lt;0.01)。神经毒性的严重程度,测量验证神经毒性分数(总神经病变评分(TNS)),显著低于接受维生素E比服用安慰剂的患者(平均TNS 1.4 vs 4.1;p & lt; 0.01). Conclusions: This phase III study confirms the neuroprotective role of vitamin E against cisplatin peripheral neurotoxicity. Vitamin E supplementation should be adopted in patients receiving cisplatin-based chemotherapy. Classification of evidence: This study provides Class II evidence that vitamin E supplementation significantly reduces the relative risk of developing signs or symptoms of neurotoxicity (relative risk = 0.14) (95% confidence interval = 0.02–1.00, p < 0.05). TNS=Total Neuropathy Score. ER -