TY - T1的腹内侧前额叶皮层调节疲劳穿透性创伤性脑损伤后JF -神经学乔-神经病学SP - 749 LP - 754 - 10.1212 / WNL。首页0 b013e3181d25b6b六世- 74 - 9盟Matteo帕帝尼非盟-弗兰克·克鲁格盟瓦妮莎Raymont AU -约旦葛夫曼Y1 - 2010/03/02 UR - //www.ez-admanager.com/content/74/9/749.abstract N2 -首页背景:疲劳是一种常见的和禁用症状在创伤性穿透大脑损伤等神经系统疾病(PBI)。尽管疲劳的患病率和影响生活质量,其病理生理学是不理解。研究工作在健康受试者感知,动物行为模式,和最近的人口在不同临床证据表明,腹内侧前额叶皮层可能发挥重要作用在神经疲劳病理生理学的条件。方法:我们招收了97名PBI患者和37对照组来自越南头部受伤研究注册表。疲劳评估自我报告问卷和医生评分工具;病变位置和体积CT扫描进行了评估。PBI患者分为3组根据病变位置:nonfrontal病变组,腹内侧前额叶皮层病变(vmPFC)组,和一个背/侧前额叶皮层(d /额叶侧皮层组织。疲劳评分比较3 PBI组和健康对照组。结果:患者vmPFC病变明显比d / lPFC病变患者疲劳,nonfrontal病变,患者和健康对照组,而后者这三组同样疲惫。 VmPFC volume was correlated with fatigue scores, showing that the larger the lesion volume, the higher the fatigue scores. Conclusions: We demonstrated that ventromedial prefrontal cortex lesion (vmPFC) plays a critical role in penetrating brain injury–related fatigue, providing a rationale to link fatigue to different vmPFC functions such as effort and reward perception. The identification of the anatomic and cognitive basis of fatigue can contribute to developing pathophysiology-based treatments for this disabling symptom. AAL=Automated Anatomic Labeling; ANOVA=analysis of variance; BDI=Beck Depression Inventory; d/lPFC=dorso/lateral prefrontal cortex; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; NBRS=Neurobehavioral Rating Scale; NF=nonfrontal lesion; PBI=penetrating brain injury; ROI=region of interest; SCID-I=Structured Clinical Interview for DSM-IV, Axis I; VHIS=Vietnam Head Injury Study; vmPFC=ventromedial prefrontal cortex lesion. ER -