TY - T1的迅速发生中央电动机可塑性在多发性硬化症JF -神经学乔-神经病学SP - 728 LP - 735 - 10.1212 / WNL。首页0 b013e3181d31dcf六世泽勒- 74 - 9盟- d . AU - k aufm Kampe Stefan盟盟——a·比勒盟——k - r .根特纳盟——a·舒兹盟——a·巴奇AU - m . Bendszus盟k v Toyka AU - p . Rieckmann AU - j·克拉森Y1 - 2010/03/02 UR - //www.ez-admanager.com/content/74/9/728.abstract N2 -目的:研究急性中央电动机可塑性首页及其运动障碍和中枢神经系统损伤的关系在多发性硬化(MS)患者。方法:在这个横断面观察研究,电机可塑性是神经生理学检查和行为在22个比较严重的患者(平均扩大残疾状态量表得分2.5[6])稳定的女士和匹配的健康对照组。首先,可塑性是评估使用配对联想刺激(PAS),长期协议建模人类皮质突触。不是结合了重复电神经刺激和经颅磁刺激(TMS)对侧运动皮层。第二,运动学习力测试的生产任务。运动障碍被功能测试评估。中枢神经系统损伤评估得到规范化N-acetyl-aspartate(乙酰天冬氨酸/ Cr)使用核磁共振光谱学和光谱corticomuscular延迟(CML)外展通过经颅磁刺激全身肌肉测试。结果:患者表现女士比控制在功能运动的测试中,乙酰天冬氨酸/ Cr cml是长期的,是降低了。PAS-induced皮质脊髓兴奋性增强,training-induced增量电动机性能的MS患者和控制之间的可比性。 Neither PAS-induced plasticity nor motor learning performance correlated with motor impairment or measures of CNS injury. Patients with high CNS injury and good motor performance did not differ significantly from those with high CNS injury and poor motor performance with respect to PAS-induced plasticity and motor learning success. Conclusions: Despite motor impairment and CNS injury in patients with multiple sclerosis (MS), rapid-onset motor plasticity is comparable to that in healthy subjects. Compensation of MS-related CNS injury is unlikely to be constrained by insufficient rapid-onset neuroplasticity. APB=abductor pollicis brevis muscle; CML=corticomuscular latency; Cr=creatine; EDSS=Expanded Disability Status Scale; GHF=good hand function; HBI=high CNS injury; LBI=low CNS injury; LTP=long-term potentiation; MEP=motor evoked potential; MS=multiple sclerosis; NAA=N-acetyl-aspartate; PAS=paired associative stimulation; PHF=poor hand function; TMS=transcranial magnetic stimulation. ER -