作者@article {Gordon666 = {E。戈登和j . d . Rohrer l·g·金和r·奥马尔·m . n . Rossor和n·c·福克斯和j·d·沃伦}title ={测量在额颞叶大叶性变性疾病进展},体积={74}={8},页面= {666 - 673}= {2010},doi = {10.1212 / WNL。出版商0 b013e3181d1a879} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:目前兴趣额颞叶大叶性变性疾病的生物标志物活动(FTLD)。首页我们评估MRI和行为措施发展的纵向FTLD队列。方法:32 FTLD患者(11行为变异额颞叶痴呆(bvFTD), 11个语义痴呆(SemD) 10进步迟滞型失语症[PNFA])和24的同龄健康对照组进行评估使用体积大脑核磁共振和标准行为措施(细微精神状态检查、额评估电池、临床痴呆评定量表、神经精神病学的库存与照顾者压力范围)在基线和1年后。半自动图像注册协议是用来计算的年化利率的脑萎缩(大脑边界积分转移[BBSI])和心室扩张(心室边界积分[VBSI])的转变。这些利率和行为指标的变化之间的联系。结果:整个大脑萎缩率要大于整个FTLD队列和在每个子群与控制(所有p < = 0.004)。心室扩张率要大于整个队列(p \ < 0.001)和SemD (p = 0.002)和PNFA (p = 0.05)子组与控制。细微精神状态检查的变化,额评估电池,和临床痴呆评定量表分数与核磁共振相关措施的进步,虽然不是均匀FTLD子组。BBSI和VBSI产生可行的样本量估计检测意义的SemD和PNFA语言子组的治疗效果。 Sample sizes were substantially larger using MRI biomarkers for the bvFTD subgroup, and using behavioral biomarkers in general. Conclusions: Semi-automated MRI atrophy measures are potentially useful objective biomarkers of progression in frontotemporal lobar degeneration (FTLD); however, careful stratification of FTLD subtypes will be important in future clinical trials of disease-modifying therapies. AD=Alzheimer disease; BBSI=brain boundary shift integral; bvFTD=behavioral variant frontotemporal dementia; CDR-SB=Clinical Dementia Rating Scale-Sums of Boxes; FTLD=frontotemporal lobar degeneration; SemD=semantic dementia; PNFA=progressive nonfluent aphasia; VBSI=ventricular boundary shift integral.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/74/8/666}, eprint = {//www.ez-admanager.com/content/74/8/666.full.pdf}, journal = {Neurology} }